Annals of Nuclear Medicine

, Volume 30, Issue 9, pp 629–636 | Cite as

Metformin discontinuation less than 72 h is suboptimal for F-18 FDG PET/CT interpretation of the bowel

  • Suk Hyun Lee
  • Soyoung Jin
  • Hyo Sang Lee
  • Jin-Sook Ryu
  • Jong Jin LeeEmail author
Original Article



Metformin-induced [F-18] fluorodeoxyglucose (FDG) bowel uptake can hinder positron emission tomography/computed tomography (PET/CT) evaluation of the bowel. This study aimed to investigate the segmental bowel uptake of FDG according to metformin discontinuation times up to 72 h.


We retrospectively divided 240 diabetic patients into four groups: metformin discontinuation <24 h (group A; n = 86), 24–48 h (group B; n = 40), 48–72 h (group C; n = 12), and no metformin (control group; n = 102). Segmental FDG bowel uptakes were measured visually (four-point scale) and semi-quantitatively (maximum standardized uptake value).


Compared with the control group, FDG uptake increased significantly from the ileum to the rectosigmoid colon in group A, from the transverse to the rectosigmoid colon in group B, and from the descending colon to the rectosigmoid colon in group C in both visual and semi-quantitative analyses.


Metformin discontinuation for <72 h is likely suboptimal for PET/CT image interpretation, especially with respect to the distal segments of the colon.


FDG PET/CT Metformin Bowel uptake Diabetes 


Compliance with ethical standards

Conflict of interest

Suk Hyun Lee, Soyoung Jin, Hyo Sang Lee, Jin-Sook Ryu, and Jong Jin Lee declare that they have no conflict of interest.


None to declare.


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Copyright information

© The Japanese Society of Nuclear Medicine 2016

Authors and Affiliations

  • Suk Hyun Lee
    • 1
  • Soyoung Jin
    • 2
  • Hyo Sang Lee
    • 3
  • Jin-Sook Ryu
    • 1
  • Jong Jin Lee
    • 1
    Email author
  1. 1.Department of Nuclear MedicineUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulKorea
  2. 2.Department of Nuclear MedicineEulgi Medical CenterSeoulKorea
  3. 3.Department of Nuclear MedicineGangneng Asan Medical CenterGangnengKorea

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