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Annals of Nuclear Medicine

, Volume 29, Issue 10, pp 921–928 | Cite as

Age-related changes in FDG brain uptake are more accurately assessed when applying an adaptive template to the SPM method of voxel-based quantitative analysis

  • Axel Van Der Gucht
  • Antoine Verger
  • Eric Guedj
  • Grégoire Malandain
  • Gabriela Hossu
  • Yalcin Yagdigul
  • Véronique Roch
  • Sylvain Poussier
  • Louis Maillard
  • Gilles Karcher
  • Pierre-Yves Marie
Original Article

Abstract

Introduction

The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [18F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images.

Methods

Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction.

Results

The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R 2 values of 0.20 and 0.07) and (2) larger extents of involved areas (13 and 5 % of whole brain template volume, respectively), leading to reveal several age-dependent areas (especially in dorsolateral prefrontal, inferior temporal/fusiform and primary somatosensory cortices).

Conclusion

Age-related changes in brain FDG uptake may be more accurately determined when applying the SPM method of voxel-based quantitative analysis on a template that best fits the characteristics of the analysed TEP images.

Keywords

18F-fluorodeoxyglucose Positron emission tomography Age Spatial normalization Statistical parametric mapping Block-Matching algorithm 

Notes

Acknowledgments

The authors thank Pierre Pothier, for critical review of the manuscript, and the Nancyclotep experimental imaging platform, for organizational support.

Compliance with ethical standards

Conflict of interest

The authors have no potential conflicts of interest to report.

Ethical standards

The procedure followed was in accordance with the ethical standards and guidelines of the responsible committee on human experimentation.

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Copyright information

© The Japanese Society of Nuclear Medicine 2015

Authors and Affiliations

  • Axel Van Der Gucht
    • 1
  • Antoine Verger
    • 1
    • 2
    • 3
  • Eric Guedj
    • 4
    • 5
  • Grégoire Malandain
    • 6
  • Gabriela Hossu
    • 7
    • 8
  • Yalcin Yagdigul
    • 1
  • Véronique Roch
    • 1
    • 2
    • 3
  • Sylvain Poussier
    • 1
    • 2
    • 3
  • Louis Maillard
    • 3
    • 9
  • Gilles Karcher
    • 1
    • 3
    • 10
  • Pierre-Yves Marie
    • 1
    • 3
    • 11
  1. 1.Department of Nuclear Medicine and Nancyclotep Experimental Imaging PlatformCHU NancyNancyFrance
  2. 2.INSERM, UMR 947NancyFrance
  3. 3.Faculty of MedicineUniversity of LorraineNancyFrance
  4. 4.Department of Nuclear MedicineAP-HM, Hospital “La Timone”MarseilleFrance
  5. 5.CNRS UMR 7289, Institut de Neurosciences de la Timone, INTMarseilleFrance
  6. 6.INRIA Sophia Antipolis-MéditerranéeSophia AntipolisFrance
  7. 7.CIC-IT, CHU NancyNancyFrance
  8. 8.INSERM, CIC-IT 1433NancyFrance
  9. 9.Department of NeurologyCHU-NancyNancyFrance
  10. 10.CRAN, UMR 7039, Université de Lorraine-CNRSVandoeuvreFrance
  11. 11.INSERM, U1116NancyFrance

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