Annals of Nuclear Medicine

, Volume 28, Issue 7, pp 664–668 | Cite as

Contrast between hypervascularized liver lesions and hepatic parenchyma: early dynamic PET versus contrast-enhanced CT

  • Martin FreesmeyerEmail author
  • Thomas Winkens
  • Jan-Henning Schierz
Original Article



To detect hypervascularized liver lesions, early dynamic (ED) 18F-FDG PET may be an alternative when contrast-enhanced (CE) imaging is infeasible. This retrospective pilot analysis compared contrast between such lesions and liver parenchyma, an important objective image quality variable, in ED PET versus CE CT.

Materials and methods

Twenty-eight hypervascularized liver lesions detected by CE CT [21 (75 %) hepatocellular carcinomas; mean (range) diameter 4.9 ± 3.5 (1–14) cm] in 20 patients were scanned with ED PET. Using regions of interest, maximum and mean lesional and parenchymal signals at baseline, arterial and venous phases were calculated for ED PET and CE CT.


Lesional/parenchymal signal ratio was significantly higher (P < 0.005) with ED PET versus CE CT at the arterial phase and similar between the methods at the venous phase.


In liver imaging, ED PET generates greater lesional–parenchymal contrast during the arterial phase than does CE CT; these observations should be formally, prospectively evaluated.


Hypervascular liver lesions Liver Contrast Contrast-enhanced computed tomography Early dynamic 18F-fluorodeoxyglucose positron emission tomography 



We thank Robert Marlowe for editing the manuscript and Dominik Driesch (Biocontrol Jena GmbH, Jena, Germany) for performing statistical analyses. This research was funded from the regular University Hospital Jena budget.

Conflict of interest



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Copyright information

© The Japanese Society of Nuclear Medicine 2014

Authors and Affiliations

  • Martin Freesmeyer
    • 1
    Email author
  • Thomas Winkens
    • 1
  • Jan-Henning Schierz
    • 1
  1. 1.Clinic of Nuclear MedicineJena University HospitalJenaGermany

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