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Annals of Nuclear Medicine

, Volume 27, Issue 10, pp 924–930 | Cite as

Recovery coefficients determination for partial volume effect correction in oncological PET/CT images considering the effect of activity outside the field of view

  • Alexandre R. KrempserEmail author
  • Roberto M. Ichinose
  • Antonio M. F. L. Miranda de Sá
  • Silvia M. Velasques de Oliveira
  • Michel P. Carneiro
Original Article

Abstract

Objectives

The partial volume effect (PVE) has a great impact in quantitative PET/CT imaging. Correction methods have been recently proposed by many authors to make the image quantification more accurate. This work presents a methodology for determining the recovery coefficients (RCs) for PVE correction in PET/CT images. It was taken into account the radioactivity outside the field of view (FOV), which is expected in a patient image acquisition.

Methods

The NEMA image quality phantom and the NEMA scatter phantom were used. The phantoms were filled with 18F-FDG for different sphere-to-background ratios. The RCs have been determined from image acquisitions in a Siemens Biograph 16 Hi-Rez PET/CT scanner with and without the scatter phantom.

Results

The RC values that ranged from 0.38 to 1.00 without the scatter phantom exhibited a wider variation when this latter was taken into account (from 0.27 to 1.02). This more realistic estimation must be considered if one takes into account that an incorrect SUV measure in tumors leads to errors in the evaluation of the response to therapy based on PET/CT images.

Conclusions

The activity outside the FOV should be considered in RCs determination to improve the RC-based PVE correction method.

Keywords

PET/CT Partial volume effect correction Recovery coefficient Activity quantification 

Notes

Acknowledgments

The authors thank the Nuclear Engineering Institute (IEN/CNEN) for providing the radiopharmaceutical needed to the phantoms and the medical physicist Tainá Olivieri for collaboration.

Conflict of interest

No potentials conflicts of interest were disclosed.

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Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Alexandre R. Krempser
    • 1
    Email author
  • Roberto M. Ichinose
    • 1
  • Antonio M. F. L. Miranda de Sá
    • 1
  • Silvia M. Velasques de Oliveira
    • 2
  • Michel P. Carneiro
    • 3
  1. 1.Biomedical Engineering ProgramFederal University of Rio de Janeiro (COPPE, UFRJ)Rio de JaneiroBrazil
  2. 2.Institute of Radiation Protection and DosimetryNational Nuclear Energy Commission (IRD, CNEN)Rio de JaneiroBrazil
  3. 3.PET/CT ClinicFleury LaboratoriesRio de JaneiroBrazil

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