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Annals of Nuclear Medicine

, Volume 27, Issue 10, pp 916–923 | Cite as

Clinical outcome prediction of percutaneous cementoplasty for metastatic bone tumor using 18F-FDG PET-CT

  • Yong-il Kim
  • Hyun Guy KangEmail author
  • Seok-ki Kim
  • June Hyuk Kim
  • Han Soo Kim
Original Article

Abstract

Objectives

Percutaneous cementoplasty (PC) is used for metastatic bone tumor. Bone metastases patients who are unable to avail regular surgery, because of their poor general condition, undergo PC to gain mechanical stability and pain relief. We evaluated the effect of PC using 18F-FDG PET-CT and investigated the correlation and predictability between quantitative parameters of 18F-FDG PET-CT and pain status after PC.

Methods

Subjects comprised 18 patients (total 32 sites) who had undergone PC for the metastatic bone tumors. Pain degree of the patients was obtained by visual analog scale (VAS) in the pre-PC, immediate post-PC, and follow-up post-PC state. As PET-CT parameters, maximum and mean standardized uptake value (MaxSUV and MeanSUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. Receiver operator characteristic curve analysis was performed for pre-PC, post-PC PET-CT, and delta (Δ) values of PET-CT parameters to correlate and predict the good pain improvement (VAS pain ≤2) after the PC procedure.

Results

Patients’ pain status improved significantly in immediate post-PC and follow-up post-PC pain (all p < 0.001). Among PET-CT parameters, MaxSUV (p = 0.004) and MeanSUV (p = 0.007) showed significant interval decrease after PC procedure. All of the post-PC PET-CT and ΔPET-CT values showed significant prediction of pain improvement for follow-up post-PC pain, especially ΔTLG (AUC = 0.804, p = 0.0003) and ΔMTV (AUC = 0.804, p = 0.0004).

Conclusions

There was significant reduction of patients’ pain after PC, and ΔTLG and ΔMTV of PET-CT parameters showed best predictability for follow-up post-PC pain improvement. PET-CT can be the useful parameter to predict treatment response of PC.

Keywords

Positron emission tomography Percutaneous cementoplasty Bone metastasis Visual analog scale Standardized uptake value Total lesion glycolysis 

Notes

Conflict of interest

The authors have no potential conflict of interest.

Supplementary material

12149_2013_771_MOESM1_ESM.doc (36 kb)
Supplementary material 1 (DOC 35 kb)

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Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Yong-il Kim
    • 1
  • Hyun Guy Kang
    • 2
    Email author
  • Seok-ki Kim
    • 3
  • June Hyuk Kim
    • 2
  • Han Soo Kim
    • 4
  1. 1.Department of Nuclear MedicineSeoul National University HospitalSeoulKorea
  2. 2.Orthopaedic Oncology ClinicNational Cancer CenterGoyang-siKorea
  3. 3.Department of Nuclear MedicineHospital and Research Institute, National Cancer CenterGoyang-siKorea
  4. 4.Department of Orthopaedic SurgerySeoul National University College of MedicineSeoulKorea

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