Advertisement

Annals of Nuclear Medicine

, Volume 27, Issue 10, pp 873–879 | Cite as

Usefulness of partial volume effect-corrected F-18 FDG PET/CT for predicting I-131 accumulation in the metastatic lymph nodes of patients with thyroid carcinoma

  • Yasuhiro Maruoka
  • Koichiro AbeEmail author
  • Shingo Baba
  • Takuro Isoda
  • Yoshiyuki Kitamura
  • Noriko Mizoguchi
  • Go Akamatsu
  • Masayuki Sasaki
  • Hiroshi Honda
Original Article

Abstract

Purpose

The purpose of this study was to evaluate the clinical usefulness of partial volume effect (PVE)-corrected F-18 FDG PET/CT for predicting I-131 accumulation in metastatic lymph nodes (mLNs) during I-131 therapy for papillary thyroid carcinoma (PTC).

Methods

Sixty-five mLNs in 31 PTC patients who underwent F-18 FDG PET/CT in an initial radioiodine therapy (RIT) were retrospectively evaluated. Of these, 25 mLNs were I-131-positive and 40 were I-131-negative. SUVmax and SUVmax with PVE correction (cSUVmax) were measured for each mLN, where PVE correction was performed utilizing a simple table lookup correction method. Then, SUVmax/cSUVmax was compared between I-131-positive and I-131-negative mLNs, including the analyses for the mLNs with small-sized (<1 cm) and weak FDG accumulation (SUVmax <3.5). The predictability for I-131 accumulation with SUVmax/cSUVmax was also compared.

Results

For all 65 mLNs, SUVmax/cSUVmax was significantly higher in I-131-negative than I-131-positive mLNs (p < 0.0001). Only in cSUVmax, I-131-negative mLNs were significantly higher than I-131-positive, in terms of the 30 small-sized mLNs (p = 0.0001) and 14 mLNs with weak FDG uptake (p = 0.007). The highest accuracy in predictability for I-131 accumulation was significantly better with cSUVmax (92 %) than SUVmax (62 %) (p < 0.0001).

Conclusion

PVE-corrected F-18 FDG PET/CT is a valuable predictor of I-131 accumulation in mLNs during RIT.

Keywords

Partial volume effect correction F-18 FDG PET/CT Thyroid carcinoma Radioiodine therapy I-131 accumulation 

References

  1. 1.
    Sherman SI. Thyroid carcinoma. Lancet. 2003;361:501–11.PubMedCrossRefGoogle Scholar
  2. 2.
    Haigh PI, Urbach DR, Rotstein LE. Extent of thyroidectomy is not a major determinant of survival in low- or high-risk papillary thyroid cancer. Ann Surg Oncol. 2005;12:81–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Bilimoria KY, Bentrem DJ, Ko CY, Stewart AK, Winchester DP, Talamonti MS, et al. Extent of surgery affects survival for papillary thyroid cancer. Ann Surg. 2007;246:375–81.PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    DeGroot LJ, Kaplan EL, McCormick M, Straus FH. Natural history, treatment, and course of papillary thyroid carcinoma. J Clin Endocrinol Metab. 1990;71:414–24.PubMedCrossRefGoogle Scholar
  5. 5.
    Machens A, Hinze R, Thomusch O, Dralle H. Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg. 2002;26:22–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Podnos YD, Smith D, Wagman LD, Ellenhorn JD. The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer. Am Surg. 2005;71:731–4.PubMedGoogle Scholar
  7. 7.
    Hay ID, McConahey WM, Goellner JR. Managing patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experience of treating 2,512 consecutive patients during 1940 through 2000. Trans Am Clin Climatol Assoc. 2002;113:241–60.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Mazzaferri EL, Kloos RT. Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab. 2001;86:1447–63.PubMedCrossRefGoogle Scholar
  9. 9.
    Simon D, Goretzki PE, Witte J, Röher HD. Incidence of regional recurrence guiding radicality in differentiated thyroid carcinoma. World J Surg. 1996;20:860–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Van Nostrand D, Wartofsky L. Radioiodine in the treatment of thyroid cancer. Endocrinol Metab Clin North Am. 2007;36:807–22.PubMedCrossRefGoogle Scholar
  11. 11.
    Luster M, Clarke SE, Dietlein M, Lassmann M, Lind P, Oyen WJ, et al. Guidelines for radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Mol Imaging. 2008;35:1941–59.CrossRefGoogle Scholar
  12. 12.
    Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.PubMedCrossRefGoogle Scholar
  13. 13.
    Tsang RW, Brierley JD, Simpson WJ, Panzarella T, Gospodarowicz MK, Sutcliffe SB. The effects of surgery, radioiodine, and external radiation therapy on the clinical outcome of patients with differentiated thyroid carcinoma. Cancer. 1998;82:375–88.PubMedCrossRefGoogle Scholar
  14. 14.
    Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 1994;97:418–28.PubMedCrossRefGoogle Scholar
  15. 15.
    Woodrum DT, Gauger PG. Role of 131I in the treatment of well differentiated thyroid cancer. J Surg Oncol. 2005;89:114–21.PubMedCrossRefGoogle Scholar
  16. 16.
    Hoie J, Stenwig AE, Kullmann G, Lindegaard M. Distant metastases in papillary thyroid cancer. A review of 91 patients. Cancer. 1998;61:1–6.CrossRefGoogle Scholar
  17. 17.
    Palmedo H, Bucerius J, Joe A, Strunk H, Hortling N, Meyka S, et al. Integrated PET/CT in differentiated thyroid cancer: diagnostic accuracy and impact on patient management. J Nucl Med. 2006;47:616–24.PubMedGoogle Scholar
  18. 18.
    Kaneko K, Abe K, Baba S, Isoda T, Yabuuchi H, Sasaki M, et al. Detection of residual lymph node metastases in high-risk papillary thyroid cancer patients receiving adjuvant I-131 therapy: the usefulness of F-18 FDG PET/CT. Clin Nucl Med. 2010;35:6–11.PubMedCrossRefGoogle Scholar
  19. 19.
    Al-Nahhas A, Khan S, Gogbashian A, Banti E, Rampin L, Rubello D. 18F-FDG PET in the diagnosis and follow-up of thyroid malignancy. In Vivo. 2008;22:109–14.PubMedGoogle Scholar
  20. 20.
    Soret M, Bacharach SL, Buvat I. Partial-volume effect in PET tumor imaging. J Nucl Med. 2007;48:932–45.PubMedCrossRefGoogle Scholar
  21. 21.
    Sakaguchi Y, Mizoguchi N, Mitsumoto T, Mitsumoto K, Himuro K, Ohya N, et al. A simple table lookup method for PET/CT partial volume correction using a point-spread function in diagnosing lymph node metastasis. Ann Nucl Med. 2010;24:585–91.PubMedCrossRefGoogle Scholar
  22. 22.
    van den Brekel MW, Stel HV, Castelijns JA, Nauta JJ, van der Waal I, Valk J, et al. Cervical lymph node metastasis: assessment of radiologic criteria. Radiology. 1990;177:379–84.PubMedGoogle Scholar
  23. 23.
    Som PM, Brandwein M, Lidov M, Lawson W, Biller HF. The varied presentations of papillary thyroid carcinoma cervical nodal disease: CT and MR findings. Am J Neuroradiol. 1994;15:1123–8.PubMedGoogle Scholar
  24. 24.
    Feine U, Lietzenmayer R, Hanke JP, Wöhrle H, Müller-Schauenburg W. 18FDG whole-body PET in differentiated thyroid carcinoma. Flipflop in uptake patterns of 18FDG and 131I. Nuklearmedizin. 1995;34:127–34.PubMedGoogle Scholar
  25. 25.
    Rousset OG, Ma Y, Evans AC. Correction for partial volume effects in PET: principle and validation. J Nucl Med. 1998;39:904–11.PubMedGoogle Scholar
  26. 26.
    Rousset OG, Collins DL, Rahmim A, Wong DF. Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatum. J Nucl Med. 2008;49:1097–106.PubMedCentralPubMedCrossRefGoogle Scholar
  27. 27.
    Geworski L, Knoop BO, de Cabrejas ML, Knapp WH, Munz DL. Recovery correction for quantitation in emission tomography: a feasibility study. Eur J Nucl Med. 2000;27:161–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Srinivas SM, Dhurairaj T, Basu S, Bural G, Surti S, Alavi A. A recovery coefficient method for partial volume correction of PET images. Ann Nucl Med. 2009;23:341–8.PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Yasuhiro Maruoka
    • 1
  • Koichiro Abe
    • 1
    Email author
  • Shingo Baba
    • 1
  • Takuro Isoda
    • 1
  • Yoshiyuki Kitamura
    • 1
  • Noriko Mizoguchi
    • 2
  • Go Akamatsu
    • 3
  • Masayuki Sasaki
    • 3
  • Hiroshi Honda
    • 1
  1. 1.Departments of Clinical RadiologyKyushu UniversityFukuokaJapan
  2. 2.Department of Medical TechnologyKyushu University HospitalFukuokaJapan
  3. 3.Departments of Health Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

Personalised recommendations