Annals of Nuclear Medicine

, Volume 27, Issue 10, pp 873–879 | Cite as

Usefulness of partial volume effect-corrected F-18 FDG PET/CT for predicting I-131 accumulation in the metastatic lymph nodes of patients with thyroid carcinoma

  • Yasuhiro Maruoka
  • Koichiro AbeEmail author
  • Shingo Baba
  • Takuro Isoda
  • Yoshiyuki Kitamura
  • Noriko Mizoguchi
  • Go Akamatsu
  • Masayuki Sasaki
  • Hiroshi Honda
Original Article



The purpose of this study was to evaluate the clinical usefulness of partial volume effect (PVE)-corrected F-18 FDG PET/CT for predicting I-131 accumulation in metastatic lymph nodes (mLNs) during I-131 therapy for papillary thyroid carcinoma (PTC).


Sixty-five mLNs in 31 PTC patients who underwent F-18 FDG PET/CT in an initial radioiodine therapy (RIT) were retrospectively evaluated. Of these, 25 mLNs were I-131-positive and 40 were I-131-negative. SUVmax and SUVmax with PVE correction (cSUVmax) were measured for each mLN, where PVE correction was performed utilizing a simple table lookup correction method. Then, SUVmax/cSUVmax was compared between I-131-positive and I-131-negative mLNs, including the analyses for the mLNs with small-sized (<1 cm) and weak FDG accumulation (SUVmax <3.5). The predictability for I-131 accumulation with SUVmax/cSUVmax was also compared.


For all 65 mLNs, SUVmax/cSUVmax was significantly higher in I-131-negative than I-131-positive mLNs (p < 0.0001). Only in cSUVmax, I-131-negative mLNs were significantly higher than I-131-positive, in terms of the 30 small-sized mLNs (p = 0.0001) and 14 mLNs with weak FDG uptake (p = 0.007). The highest accuracy in predictability for I-131 accumulation was significantly better with cSUVmax (92 %) than SUVmax (62 %) (p < 0.0001).


PVE-corrected F-18 FDG PET/CT is a valuable predictor of I-131 accumulation in mLNs during RIT.


Partial volume effect correction F-18 FDG PET/CT Thyroid carcinoma Radioiodine therapy I-131 accumulation 


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Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Yasuhiro Maruoka
    • 1
  • Koichiro Abe
    • 1
    Email author
  • Shingo Baba
    • 1
  • Takuro Isoda
    • 1
  • Yoshiyuki Kitamura
    • 1
  • Noriko Mizoguchi
    • 2
  • Go Akamatsu
    • 3
  • Masayuki Sasaki
    • 3
  • Hiroshi Honda
    • 1
  1. 1.Departments of Clinical RadiologyKyushu UniversityFukuokaJapan
  2. 2.Department of Medical TechnologyKyushu University HospitalFukuokaJapan
  3. 3.Departments of Health Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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