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Annals of Nuclear Medicine

, Volume 27, Issue 10, pp 935–941 | Cite as

Massive accumulation of 11C-Pittsburg compound B in the occipital lobes of a patient with early-onset dementia accompanied by muscle weakness and hypertonicity

  • Kimiteru ItoEmail author
  • Terunori Sano
  • Kouhei Kamiya
  • Yasuhiro Nakata
  • Yoko Shigemoto
  • Noriko Sato
  • Yasushi Oya
  • Hiroshi Matsuda
Case Report

Abstract

A 44-year-old woman underwent 11C-Pittsburg compound B (11C-PiB), 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT), 99mTc-ethyl-cysteinate-dimer single photon emission computed tomography, and magnetic resonance imaging after presenting with progressive dementia, muscle weakness, and hypertonicity. Some of her family members had died of muscle weakness with early-onset dementia of unknown etiology. Neurological and psychological examinations revealed moderate dementia in general fields and muscle weakness in her upper limbs. 11C-PiB PET/CT revealed abnormal accumulations of amyloid in the bilateral occipital lobes, while physiological uptakes of 11C-PiB in areas that normally show high uptake, such as white matter, appeared relatively decreased. Meanwhile, cerebrospinal fluid (CSF) amyloid-β was decreased, and CSF total and phosphorylated tau proteins were increased. This case may be representative of a new category of amyloid deposition disease characterized by early-onset dementia, muscle weakness, and hypertonicity, or at least, a new uptake pattern of PiB in variant AD.

Keywords

Occipital lobe 11C-PiB 18F-FDG Early-onset dementia Muscle weakness 

Notes

Conflict of interest

None.

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Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Kimiteru Ito
    • 1
    Email author
  • Terunori Sano
    • 2
  • Kouhei Kamiya
    • 1
  • Yasuhiro Nakata
    • 1
  • Yoko Shigemoto
    • 1
  • Noriko Sato
    • 1
  • Yasushi Oya
    • 2
  • Hiroshi Matsuda
    • 3
  1. 1.Department of RadiologyNational Center of Neurology and PsychiatryKodairaJapan
  2. 2.Department of NeurologyNational Center of Neurology and PsychiatryTokyoJapan
  3. 3.Integrative Brain Imaging Center, National Center of Neurology and PsychiatryTokyoJapan

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