Annals of Nuclear Medicine

, Volume 27, Issue 3, pp 271–278 | Cite as

Appropriate collimators in a small animal SPECT scanner with CZT detector

  • Yusuke Higaki
  • Masato KobayashiEmail author
  • Tomoya Uehara
  • Hirofumi Hanaoka
  • Yasushi Arano
  • Keiichi Kawai
Original Article



Almost all small animal SPECT is performed with pinhole collimators (PH), including single-PH (SPH) and multi-PH (MPH). In the clinical study, not only PH but also parallel-hole collimator (PAH) is often used in planar and SPECT imaging. However, there have been no comparative studies on image quality with various collimators on the small animal imaging. This study compared the basic characteristics of PH and PAH in small animal imaging.


Performance of planar and SPECT images was evaluated using 99mTcO4 and SPH, MPH and PAH with low energy and high resolution on the SPECT/CT scanner FX3200. We measured sensitivity, resolution, concentration linearity and uniformity. Planar imaging of mice with 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3) was performed using SPH and PAH. SPECT imaging with 99mTc-methylene diphosphonate (99mTc-MDP) was performed using all collimators.


With SPH, MPH and PAH, sensitivity was 43.5, 211.2 and 926.5 cps/MBq, respectively, and spatial resolution was 0.60/0.56, non/0.96, 5.20/5.34 mm full-width half maximum (planar/SPECT), respectively. There were marked correlations between the radioactivity counts on images and radioactivity with all collimators. Values of % standard deviation on planar imaging showed small differences between the SPH and PAH, while the values were the smallest on SPECT imaging with MPH. On imaging of mice, SPH yielded high-quality 99mTc-MAG3-planar images when compared with PAH. MPH yielded sharper 99mTc-MDP-SPECT images than SPH and PAH.


The characteristics of PH and PAH differed on small animal imaging. Although sensitivity was higher with PAH, PH showed higher resolution. Among the PH collimators, SPH was more appropriate for planar imaging, and MPH was more suitable for SPECT imaging in a small animal imaging scanner with CZT detector.


Small animal imaging Planar imaging SPECT imaging Pinhole collimator Parallel-hole collimator 



The author would like to thank the staff of Chiba University for their technical assistance. This study was partly funded by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science (23659578, 23659579, 24601008, and 24659558).


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Copyright information

© The Japanese Society of Nuclear Medicine 2013

Authors and Affiliations

  • Yusuke Higaki
    • 1
    • 2
  • Masato Kobayashi
    • 1
    Email author
  • Tomoya Uehara
    • 2
  • Hirofumi Hanaoka
    • 2
  • Yasushi Arano
    • 2
  • Keiichi Kawai
    • 1
    • 3
  1. 1.Graduate School of Health Sciences, College of Medical, Pharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan
  2. 2.Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan
  3. 3.Biomedical Imaging Research CenterUniversity of FukuiFukuiJapan

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