Annals of Nuclear Medicine

, Volume 26, Issue 10, pp 794–803 | Cite as

Diagnostic performance of planar scintigraphy using 99mTc-MIBI in patients with secondary hyperparathyroidism: a meta-analysis

  • Carmelo CaldarellaEmail author
  • Giorgio Treglia
  • Alfredo Pontecorvi
  • Alessandro Giordano
Original article



Parathyroid scintigraphy using 99mTc-MIBI is not currently considered a valuable diagnostic tool for the localization of involved glands in patients with secondary hyperparathyroidism (SHPT). However, published data about its diagnostic accuracy are discordant and a meta-analysis about this topic is still lacking. The aim of our study is to meta-analyze the published data about the diagnostic performance of 99mTc-MIBI parathyroid scintigraphy in patients with SHPT.


A comprehensive computer literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through September 2011 and regarding the diagnostic accuracy of 99mTc-MIBI parathyroid scintigraphy in patients with SHPT was carried out. Only articles in English language in which at least 10 patients with SHPT underwent planar 99mTc-MIBI parathyroid scintigraphy were selected. Pooled sensitivity, pooled specificity and area under the ROC curve on a per lesion-based analysis were calculated to measure the diagnostic accuracy of 99mTc-MIBI parathyroid scintigraphy in SHPT patients.


Twenty-four studies comprising 471 patients were included in this meta-analysis. The pooled sensitivity and specificity of 99mTc-MIBI parathyroid scintigraphy in detecting hyperplastic glands in SHPT patients were 58 % [95 % confidence interval (95 % CI) 52–65 %] and 93 % (95 % CI 85–100 %), respectively, on a per lesion-based analysis. Area under ROC curve was 0.75.


In patients with SHPT and diffuse or nodular hyperplasia, planar parathyroid scintigraphy using 99mTc-MIBI has demonstrated an inadequate diagnostic accuracy. Therefore, it should not be considered as a first-line diagnostic imaging method in the pre-surgical detection of hyperplastic parathyroid glands.


Parathyroid scintigraphy Secondary hyperparathyroidism Meta-analysis Diagnostic accuracy 


Conflict of interest



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Copyright information

© The Japanese Society of Nuclear Medicine 2012

Authors and Affiliations

  • Carmelo Caldarella
    • 1
    Email author
  • Giorgio Treglia
    • 1
  • Alfredo Pontecorvi
    • 2
  • Alessandro Giordano
    • 1
  1. 1.Department of Bioimaging and Radiological Sciences, Institute of Nuclear MedicineCatholic University of the Sacred HeartRomeItaly
  2. 2.Department of Internal Medicine, Institute of EndocrinologyCatholic University of the Sacred HeartRomeItaly

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