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Annals of Nuclear Medicine

, Volume 25, Issue 10, pp 804–811 | Cite as

The value of 18F-FDG-PET/CT in the differential diagnosis of solitary pulmonary nodules in areas with a high incidence of tuberculosis

  • YaLun Li
  • Minggang Su
  • Fanglan Li
  • Anren Kuang
  • Rong TianEmail author
Original article

Abstract

Objective

The purpose of this study was to evaluate 18F-FDG-PET, PET/CT, and CT in the diagnosis of benign or malignant solitary pulmonary nodules (SPNs) in areas with a high incidence of TB.

Methods

Ninety-six patients with a SPN smaller than 30 mm were studied prospectively. PET/CT images were obtained 60 min after intravenous injection of 18F-FDG. The data obtained for each patient were analyzed and the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated and compared using χ2 test.

Results

The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 86.7, 72.2, 81.3, 83.9, and 76.5%, respectively, for CT and 88.3, 61.1, 79.1, 79.1, and 75.9%, respectively, for PET. Tuberculosis was responsible for 57.1% (8/14) of false-positives on PET. The sensitivity, specificity, accuracy, PPV, and NPV in the diagnosis of SPN were 96.7, 75.7, 88.5, 88.1, and 94.4% for PET/CT. The accuracy of PET/CT was higher than that of either CT or PET alone (P < 0.05).

Conclusion

PET has a high false-positive rate in areas with a high incidence of TB; combined PET and CT (PET/CT) can improve the diagnostic accuracy in the differentiation of an SPN.

Keywords

18F-FDG Solitary pulmonary nodule Positron emission tomography Computed tomography 

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Copyright information

© The Japanese Society of Nuclear Medicine 2011

Authors and Affiliations

  • YaLun Li
    • 1
  • Minggang Su
    • 2
  • Fanglan Li
    • 2
  • Anren Kuang
    • 2
  • Rong Tian
    • 2
    Email author
  1. 1.Department of Respiratory MedicineWest China Hospital, Sichuan UniversityChengduChina
  2. 2.Department of Nuclear MedicineWest China Hospital, Sichuan UniversityChengduChina

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