Annals of Nuclear Medicine

, Volume 25, Issue 4, pp 303–307 | Cite as

A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma

  • Koichiro Kaneko
  • Akihiro Nishie
  • Fumitou Arima
  • Tsuyoshi Yoshida
  • Ken Ono
  • Junichi Omagari
  • Hiroshi Honda
Case Report


Primary hepatic lymphoma (PHL) is a very rare disease, especially in the diffuse type. We report a case of a middle-aged man with hepatitis C virus infection who developed diffuse-type PHL mimicking diffuse hepatocellular carcinoma (HCC). Contrast-enhanced computed tomography (CT) and magnetic resonance imaging showed diffusely infiltrated hypovascular lesions throughout the liver, but no intrahepatic portal venous thrombus was observed. Diffusion-weighted imaging and 18F-FDG positron emission tomography/CT, respectively, showed a very low apparent diffusion coefficient value and high FDG uptake. These findings were more suggestive of diffuse-type PHL than diffuse HCC. Liver biopsy examination confirmed a diagnosis of diffuse large B-cell lymphoma. Systemic staging revealed no evidence of nodal or bone marrow involvement, so PHL was diagnosed. The patient was treated with chemotherapy and achieved complete remission. We suggest that a combination of image modalities may enable differentiation of diffuse-type PHL from diffuse HCC.


Diffuse-type primary hepatic lymphoma 18F-FDG-PET/CT Diffusion-weighted MRI Diffuse hepatocellular carcinoma 


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Copyright information

© The Japanese Society of Nuclear Medicine 2011

Authors and Affiliations

  • Koichiro Kaneko
    • 1
  • Akihiro Nishie
    • 4
  • Fumitou Arima
    • 2
  • Tsuyoshi Yoshida
    • 1
  • Ken Ono
    • 3
  • Junichi Omagari
    • 3
  • Hiroshi Honda
    • 4
  1. 1.PET Imaging CenterKoga Hospital 21KurumeJapan
  2. 2.Department of HematologyKoga Hospital 21KurumeJapan
  3. 3.Department of RadiologyKoga Hospital 21KurumeJapan
  4. 4.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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