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Annals of Nuclear Medicine

, Volume 24, Issue 1, pp 35–39 | Cite as

Incidental detection of Sertoli–Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome

  • Tamer ÖzülkerEmail author
  • Tevfik Özpaçacı
  • Filiz Özülker
  • Ümit Özekici
  • Remziye Bilgiç
  • Meral Mert
Case Report

Abstract

A 29-year-old female patient who was being followed up for differentiated papillary thyroid carcinoma was referred to us for exploration of any possible metastasis since her serum thyroglobulin levels were high. The patient underwent an F-18 fluorodeoxyglucose positron emission tomography study, and a pathologically increased FDG uptake at the left lower abdomen was detected corresponding to a solid, cystic lesion on CT images. The patient had a history of primary amenorrhea and, together with the magnetic resonance imaging findings of absent uterus, short and blind end vagina, a diagnosis of androgen insensitivity syndrome was made. The patient underwent laparoscopic left pelvic mass resection, and the histopathology of the lesion revealed Sertoli–Leydig cell tumor.

Keywords

Sertoli–Leydig cell tumor Androgen insensitivity syndrome FDG PET 

References

  1. 1.
    Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol. 1953;65:1192.PubMedGoogle Scholar
  2. 2.
    Bowen P, Lee CS, Migeon CJ, Kaplan NM, Whalley PJ, Mckusik VA, et al. Hereditary male pseudohermaphroditism with hypogonadism, hypospadias and gynecomastia: Reifenstein’s syndrome. Ann Int Med. 1965;62:252.PubMedGoogle Scholar
  3. 3.
    Goldberg MB, Maxwell AF. Male pseudohermaphroditism proved by surgical exploration and microscopic examination. A case report with speculations concerning pathogenesis. J Clin Endocrinol. 1948;8:367.CrossRefGoogle Scholar
  4. 4.
    Hughes I, Deeb A. Androgen resistance. Best Pract Res Clin Endocrinol Metab. 2006;20:577.CrossRefPubMedGoogle Scholar
  5. 5.
    Grumbach MN. Disorders of sex differentiation. In: Larsen PR, editor. Williams textbook of endocrinology. Philadelphia: Saunders; 2003. p. 842–1002.Google Scholar
  6. 6.
    Bangsboll S, Qvist I, Lebech PE, Lewinsky MS. Testicular feminization syndrome and associated gonadal tumors in Denmark. Acta Obstet Gynecol Scand. 1992;71:63.CrossRefPubMedGoogle Scholar
  7. 7.
    Boehmer AL, Brinkmann O, Brüggenwirth H. Genotype versus phenotype in families with androgen insensitivity syndrome. J Clin Endocrinol Metab. 2001;86:4151.CrossRefPubMedGoogle Scholar
  8. 8.
    Oakes MB, Eyvazzadeh AD, Quint E, Smith YR. Complete androgen insensitivity syndrome—a review. J Pediatr Adolesc Gynecol. 2008;21(6):305–10.CrossRefPubMedGoogle Scholar
  9. 9.
    Baksu A, Kabukcuoglu F, Baksu B, Goker N. Bilateral Sertoli cell adenoma and serous cyst in a patient with androgen insensitivity syndrome. Eur J Obstet Gynecol Reprod Biol. 2004;114(1):104–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T. Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol. 2005;96(3):870–2.CrossRefPubMedGoogle Scholar
  11. 11.
    Nguyen BD. PET imaging of Sertoli cell tumor in androgen insensitivity syndrome. Clin Nucl Med. 2003;28(9):743–5.CrossRefPubMedGoogle Scholar
  12. 12.
    Hannema SE, Scott IS, Rajpert-De Meyts E, Skakkebaek NE, Coleman N, Hughes IA. Testicular development in the complete androgen insensitivity syndrome. J Pathol. 2006;208(4):518–27.CrossRefPubMedGoogle Scholar
  13. 13.
    Rutgers JL, Scully RE. The androgen insensitivity syndrome (testicular feminization): a clinicopathologic study of 43 cases. Int J Gynecol Pathol. 1991;10(2):126–44.PubMedCrossRefGoogle Scholar
  14. 14.
    Ayhan A, Tuncer ZS, Hakverdi AU, Yuce K. Sertoli–Leydig cell tumors of the ovary: a clinicopathologic study of 10 cases. Eur J Gynaecol Oncol. 1995;17:75–8.Google Scholar
  15. 15.
    Choong CS, Fuller PJ, Chu S, Jeske Y, Bowling F, Brown R, et al. Sertoli–Leydig cell tumor of the ovary: a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49–56.CrossRefPubMedGoogle Scholar
  16. 16.
    Jarzabek K, Philibert P, Koda M, Sulkowski S, Kotula-Balak M, Bilinska B, et al. Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli–Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. Gynecol Endocrinol. 2007;23(9):499–504.CrossRefPubMedGoogle Scholar
  17. 17.
    Young RH, Scully RE. Ovarian Sertoli–Leydig cell tumors: a clinicopathological analysis of 207 cases. Am J Surg Pathol. 1985;9:543–69.CrossRefPubMedGoogle Scholar
  18. 18.
    Cremerius U, Effert PJ, Adam G, Sabri O, Zimmy M, Wagenknecht G, et al. FDG PET for detection and therapy control of metastatic germ cell tumor. J Nucl Med. 1998;39(5):815–22.PubMedGoogle Scholar

Copyright information

© The Japanese Society of Nuclear Medicine 2009

Authors and Affiliations

  • Tamer Özülker
    • 1
    • 5
    Email author
  • Tevfik Özpaçacı
    • 1
  • Filiz Özülker
    • 1
  • Ümit Özekici
    • 2
  • Remziye Bilgiç
    • 3
  • Meral Mert
    • 4
  1. 1.Department of Nuclear MedicineOkmeydanı Training and Research HospitalIstanbulTurkey
  2. 2.Department of Obstetrics and GynecologyÇevre HospitalIstanbulTurkey
  3. 3.E-sitopatoloji, Pathology CenterIstanbulTurkey
  4. 4.Department of Internal MedicineOkmeydanı Training and Research HospitalIstanbulTurkey
  5. 5.Darüşşafaka Mah. Gazeteciler SitesiIstanbulTurkey

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