Annals of Nuclear Medicine

, Volume 23, Issue 9, pp 771–776 | Cite as

Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis

  • Kenichi Nakajima
  • Anri Inaki
  • Takashi Hiramatsu
  • Minoru Hasegawa
  • Manabu Fujimoto
  • Kazuhiko Takehara
  • Seigo Kinuya
Original Article

Abstract

Objectives

Esophageal complications are common in patients with systemic sclerosis (SSc). The relationship between gastroesophageal reflux (GER) symptoms and dysmotility was examined in endoscopically confirmed patients suspected of having reflux esophagitis.

Methods

A total of 32 patients with limited and diffuse type SSc (lSSc, dSSc) were examined based on a structured questionnaire score (QS) of GER symptoms, retention fraction of esophageal scintigraphy at 90 s (R90) and gastric emptying time.

Results

The QS was significantly higher in the reflux esophagitis group than in the non-esophagitis group (5.4 ± 3.5, 1.4 ± 2.9, P = 0.003). When the non-esophagitis group was further divided into lSSc and dSSc groups, R90 was higher in the reflux esophagitis group (31 ± 18%) and the non-esophagitis group with dSSc (34 ± 32%) than in the non-esophagitis group with lSSc (8 ± 3%, P = 0.02). Both high R90 ≥ 15% and QS ≥ 4 indicated reflux esophagitis. Conversely, both normal R90 and QS indicated no reflux esophagitis.

Conclusion

A combination of esophageal scintigraphy and structured questionnaire demonstrated different aspects of esophageal dysfunction, namely dysmotility and GER. Patients with high QS and dysmotility may be indicated for further evaluation including endoscopic examination and medical treatment.

Keywords

Systemic sclerosis Esophageal transit scintigraphy Esophageal dysmotility Gastroesophageal reflux Structured questionnaire 

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Copyright information

© The Japanese Society of Nuclear Medicine 2009

Authors and Affiliations

  • Kenichi Nakajima
    • 1
  • Anri Inaki
    • 1
  • Takashi Hiramatsu
    • 1
  • Minoru Hasegawa
    • 2
  • Manabu Fujimoto
    • 2
  • Kazuhiko Takehara
    • 2
  • Seigo Kinuya
    • 1
  1. 1.Department of Nuclear MedicineKanazawa University HospitalKanazawaJapan
  2. 2.Department of DermatologyKanazawa University HospitalKanazawaJapan

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