90Y bremsstrahlung emission computed tomography using gamma cameras
This study demonstrates images obtained by 90Y bremsstrahlung emission computed tomography (BECT), and characterizes the system performance of gamma cameras.
90Y BECT images of phantoms were acquired using a gamma camera equipped with a medium energy general purpose parallel-hole collimator. Three energy window widths of 50% (57–94 keV) centered at 75 keV, 30% (102–138 keV) at 120 keV, and 50% (139–232 keV) at 185 keV were set on a 90Y bremsstrahlung spectrum. The images obtained with three energy windows were reconstructed using filtered back projection (FBP) and ordered subsets expectation maximization (OSEM) methods. The images of the sum window were obtained by fusing the images of the 75, 120, and 185 keV windows.
The OSEM method improved the full width at half maximum by 20% and the standard deviation by 9% compared with the FBP method. BECT displayed 90Y biodistribution and quantified 90Y activity. BECT images obtained with OSEM method using the 120 keV window showed the highest resolution and lowest uncertainty. The sum window showed the highest sensitivity, while its resolution was 10% inferior to that of the 120 keV window. One whole-body image can be taken over 100 min using the sum window. An absorber to cover the body surface reduced background by 30%.
90Y BECT imaging can be used for patient assessment without modifying current treatment procedures.
Keywords90Y-Ibritumomab tiuxetan 90Y bremsstrahlung Emission computed tomography Gamma camera
- 1.Biogen Idec Inc. Zevalin (ibritumomab tiuxetan). San Diego: Biogen Idec Inc.; 2005.Google Scholar
- 4.Witzig TE, Gordon LI, Cabanillas F, Czuczman MS, Emmanouilides C, Joyce R, et al. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin’s lymphoma. J Clin Oncol. 2002;20:2453–63.PubMedCrossRefGoogle Scholar
- 6.Firestone RB, Shirley VS, editors. Table of isotopes. 8th ed. New York: Wiley; 1996.Google Scholar
- 7.Knoll GF. Radiation detection and measurement. 2nd ed. New York: Wiley; 1989.Google Scholar
- 8.Williams PL, editor. Gray’s anatomy. 37th ed. Edinburgh: Churchill Livingstone; 1989.Google Scholar
- 9.Conti PS, White C, Pieslor P, Molina A, Aussie J, Foster P. The role of imaging with 111In-ibritumomab tiuxetan in the ibritumomab tiuxetan (Zevalin) regimen: results from a Zevalin Imaging Registry. J Nucl Med. 2005;46:1813–8.Google Scholar
- 10.Naruki Y, Carrasquillo JA, Reynolds JC, Maloney PJ, Frincke JM, Neumann RD, et al. Differential cellular catabolism of indium-111, yttrium-90 and iodine-125 radiolabeled T101 and anti-CD5 monoclonal antibody. Nucl Med Biol. 1990;17:201–8.Google Scholar
- 11.Otte A. Diagnostic imaging prior to 90Y-ibritumomab tiuxetan (Zevalin®) treatment in follicular non-Hodgkin’s lymphoma. Hell J Nucl Med. 2008;1:12–5.Google Scholar
- 19.Subcommittee for Standardization of Radionuclide Imaging, Medical and Pharmaceutical Committee. Test conditions of performance of single photon emission computed tomography unit. Radioisotopes 1984;33:162–9. (in Japanese)Google Scholar
- 20.National Electrical Manufacturers Association. Performance measurements of scintillation camera (NEMA Standards Publication No. NU1-1994). Washington, DC: NEMA;1994.Google Scholar
- 26.Lee KH. Computers in nuclear medicine: a practical approach. New York: The Society of Nuclear Medicine; 1991.Google Scholar
- 30.Ogawa K, Ichihara T, Kubo A. Accurate scatter correction in single-photon emission CT. Ann Nucl Med Sci. 1994;7:145–50.Google Scholar