Annals of Nuclear Medicine

, Volume 22, Issue 6, pp 513–519 | Cite as

Quantitative evaluation of norcholesterol scintigraphy, CT attenuation value, and chemical-shift MR imaging for characterizing adrenal adenomas

  • Teruaki Yoh
  • Makoto HosonoEmail author
  • Yoshihiro Komeya
  • Sung-Woon Im
  • Ryuichiro Ashikaga
  • Taro Shimono
  • Norio Tsuchiya
  • Masahiro Okada
  • Kazushi Hanada
  • Yukinobu Yagyu
  • Yasumasa Nishimura
  • Takamichi Murakami
Original Article



The objective of our study was to evaluate diagnostic ability and features of quantitative indices of three modalities: uptake rate on norcholesterol scintigraphy, computed tomography (CT) attenuation value, and fat suppression on chemical-shift magnetic resonance imaging (MRI) for characterizing adrenal adenomas.


Image findings of norcholesterol scintigraphy, CT, and MRI were reviewed for 78 patients with functioning (n = 48) or nonfunctioning (n = 30) adrenal masses. The norcholesterol uptake rate, attenuation value on unenhanced CT, and suppression on in-phase to opposed-phase MRI were measured for adrenal masses.


The norcholesterol uptake rate, CT attenuation value, and MR suppression index showed the sensitivity of 60%, 82%, and 100%, respectively, for functioning adenomas of <2.0 cm, and 96%, 79%, and 67%, respectively, for those of ≥2.0 cm. A statistically significant correlation was observed between size and norcholesterol uptake, and between CT attenuation value and MR suppression index. Regarding norcholesterol uptake, the adenoma-to-contralateral gland ratio was significantly higher in cortisol releasing than in aldosterone-releasing adenomas.


The norcholesterol uptake rate was reliable for characterization of adenomas among adrenal masses of ≥2.0 cm. CT attenuation value and MR suppression index were well correlated with each other, and were useful regardless of mass size.


Adrenal adenoma Norcholesterol CT MRI Chemical-shift imaging 


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Copyright information

© The Japanese Society of Nuclear Medicine 2008

Authors and Affiliations

  • Teruaki Yoh
    • 1
  • Makoto Hosono
    • 2
    Email author
  • Yoshihiro Komeya
    • 2
  • Sung-Woon Im
    • 2
  • Ryuichiro Ashikaga
    • 1
  • Taro Shimono
    • 1
  • Norio Tsuchiya
    • 2
  • Masahiro Okada
    • 2
  • Kazushi Hanada
    • 2
  • Yukinobu Yagyu
    • 1
  • Yasumasa Nishimura
    • 3
  • Takamichi Murakami
    • 1
  1. 1.Department of RadiologyKinki University School of MedicineOsaka-SayamaJapan
  2. 2.Department of Positron Emission TomographyKinki University School of MedicineOsaka-SayamaJapan
  3. 3.Department of Radiation OncologyKinki University School of MedicineOsaka-SayamaJapan

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