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Annals of Nuclear Medicine

, Volume 22, Issue 1, pp 1–11 | Cite as

PET kinetic analysis: error consideration of quantitative analysis in dynamic studies

  • Yoko IkomaEmail author
  • Hiroshi Watabe
  • Miho Shidahara
  • Mika Naganawa
  • Yuichi Kimura
Review Article

Abstract

Positron emission tomography dynamic studies have been performed to quantify several biomedical functions. In a quantitative analysis of these studies, kinetic parameters were estimated by mathematical methods, such as a nonlinear least-squares algorithm with compartmental model and graphical analysis. In this estimation, the uncertainty in the estimated kinetic parameters depends on the signal-to-noise ratio and quantitative analysis method. This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models.

Keywords

PET Compartmental model Error analysis 

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Copyright information

© The Japanese Society of Nuclear Medicine 2008

Authors and Affiliations

  • Yoko Ikoma
    • 1
    Email author
  • Hiroshi Watabe
    • 1
  • Miho Shidahara
    • 2
  • Mika Naganawa
    • 2
    • 3
  • Yuichi Kimura
    • 2
  1. 1.Department of Investigative RadiologyNational Cardiovascular Center Research InstituteSuitaJapan
  2. 2.Molecular Imaging CenterNational Institute of Radiological SciencesChibaJapan
  3. 3.Japan Society for the Promotion of ScienceTokyoJapan

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