Annals of Nuclear Medicine

, Volume 21, Issue 6, pp 349–354

Effects of smoking on the lung accumulation of [11C]McN5652

  • Akihiro Takano
  • Hiroshi Ito
  • Yasuhiko Sudo
  • Makoto Inoue
  • Tetsuya Ichimiya
  • Fumihiko Yasuno
  • Kazutoshi Suzuki
  • Tetsuya Suhara
short communication

Abstract

Objective

The lung is one of the key organs for determining the distribution of drugs in the human body. Various factors influence the accumulation of drugs. In this study, we investigated the effects of smoking on drug distribution to the lung using radiolabeled drugs.

Methods

We measured the lung uptake of [11C](+)McN5652, a radioligand for serotonin transporter (5-HTT), and inactive enantiomer [11C](−)McN5652 in 19 healthy men (12 nonsmokers and 7 smokers) using positron emission tomography. Pretreatment study was performed by the administration of clomipramine (50 mg), a potent 5-HTT inhibitor.

Results

The mean lung uptake of [11C](+)McN5652 and [11C](−)McN5652 was significantly higher in smokers than in nonsmokers. The lung uptake of [11C](+)McN5652 decreased after pretreatment with clomipramine, whereas that of [11C](−)McN5652 was not affected by clomipramine.

Conclusions

Lung uptake of [11C](−)McN5652 was influenced by smoking, possibly because the probable nonspecific binding accumulation was changed as [11C](−)McN5652 was reported to have negligible affinity to 5-HTT. Smoking might be one of the important factors when distribution of radioligands is considered.

Key words

Keywords Nonspecific binding [11C]McN5652 Smoking Microdosing Lung 

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Copyright information

© The Japanese Society of Nuclear Medicine 2007

Authors and Affiliations

  • Akihiro Takano
    • 1
  • Hiroshi Ito
    • 1
  • Yasuhiko Sudo
    • 1
  • Makoto Inoue
    • 1
  • Tetsuya Ichimiya
    • 1
  • Fumihiko Yasuno
    • 1
  • Kazutoshi Suzuki
    • 1
  • Tetsuya Suhara
    • 1
  1. 1.Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging CenterNational Institute of Radiological SciencesChibaJapan

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