Annals of Nuclear Medicine

, Volume 21, Issue 4, pp 189–196

Diagnostic performance of CT, PET, side-by-side, and fused image interpretations for restaging of non-Hodgkin lymphoma

  • Munenobu Nogami
  • Yuji Nakamoto
  • Setsu Sakamoto
  • Kazuto Fukushima
  • Tomohisa Okada
  • Tsuneo Saga
  • Tatsuya Higashi
  • Michio Senda
  • Toshimitsu Matsui
  • Kazuro Sugimura
ORIGINAL ARTICLE

DOI: 10.1007/s12149-007-0015-1

Cite this article as:
Nogami, M., Nakamoto, Y., Sakamoto, S. et al. Ann Nucl Med (2007) 21: 189. doi:10.1007/s12149-007-0015-1

Abstract

Objective

The purpose of this study was to compare the diagnostic performance of positron emission tomography (PET) alone, computed tomography (CT) alone, side-by-side reading, and fused images for restaging or follow-up of patients with malignant lymphoma.

Methods

Fifty patients with histologically confirmed non-Hodgkin lymphoma underwent an 18fluoro-2-deoxyglucose (FDG)-PET scan, followed by a CT scan. CT alone, PET alone, side-by-side reading, and fused images were interpreted separately and visually using a five-point grading scale for the following eight regions: cervical, supraclavicular, axillary, mediastinal, para-aortic to iliac, mesenteric, inguinal, and extra-nodal. Diagnostic accuracy was compared on the basis of the final diagnoses determined by histological confirmation and/or clinical course.

Results

For all regions combined, the interpretation of PET alone (sensitivity = 86.1%, specificity = 99.4%, accuracy = 91.0%), side-by-side reading (96.0%, 99.4%, 98.9%), and fused images (98.0%, 99.4%, 99.2%) yielded significantly higher diagnostic performance than that of CT alone (59.4%, 96.1%, 91.0%; P < 0.001). The cervical, supraclavicular, and extra-nodal regions were more accurately diagnosed with PET (P < 0.05), whereas the para-aortic to iliac regions were diagnosed more accurately with side-by-side reading and fused images than with CT alone or PET alone (P < 0.05).

Conclusions

Although fused images are clinically valuable, side-by-side reading showed equivalent performance, whereas the interpretation of PET alone yielded reasonably high diagnostic performance for restaging or follow-up of patients with malignant lymphoma.

Key words

CT PET Lymphoma Image fusion 

Copyright information

© The Japanese Society of Nuclear Medicine 2007

Authors and Affiliations

  • Munenobu Nogami
    • 1
  • Yuji Nakamoto
    • 2
  • Setsu Sakamoto
    • 1
  • Kazuto Fukushima
    • 3
  • Tomohisa Okada
    • 4
  • Tsuneo Saga
    • 2
  • Tatsuya Higashi
    • 2
  • Michio Senda
    • 5
  • Toshimitsu Matsui
    • 6
  • Kazuro Sugimura
    • 1
  1. 1.Department of RadiologyKobe University Graduate School of MedicineKobeJapan
  2. 2.Department of Diagnostic Imaging and Nuclear MedicineKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of Nuclear MedicineNational Cardiovascular CenterOsakaJapan
  4. 4.Department of RadiologyKobe City General HospitalKobeJapan
  5. 5.Department of Image-Based MedicineInstitute of Biomedical Research and InnovationKobeJapan
  6. 6.Division of Hematology/Oncology, Department of MedicineKobe University School of MedicineKobeJapan

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