Ageing International

, Volume 41, Issue 3, pp 265–282 | Cite as

The Aging as a Consequence of Diverse Biological Processes

  • Nicolas Coronel-Restrepo
  • Fabio Bonilla-Abadía
  • Andres Agualimpia
  • Andrés F. Echeverri
  • Fabio E. Ospina
  • Carlos A. Cañas
  • Gabriel J. Tobón


There are many theories that have proposed in order to understand the aging process, and the interpretation of these theories does not reflect an unified concept. With aging, the loss of functional and developmental capacity is evidenced, this reflecting a loss of operational ability of different cells, which are unavailable to function under the gene and environment pressure. Among the mechanisms of homeodynamics, the repair and synthesis of DNA, the capacity to detect and depure proteins, lipids, organelles and defective cells, amongst others, are all well described. The process of homeodynamics also works to maintain proper immune function that is capable of defending against pathogens and recognizing self-antigens in order to prevent the development of autoimmunity and to maintain a controlled inflammatory response. Based on this fundamental concept of homeodynamics, it has been possible to explain the mechanisms that contribute to the process of aging, in contrast to the physiological maintenance of the different pathways (e.g., DNA damage, DNA errors, free radicals, mitochondrial damage, injury/cell insult and theories of immunosenescence) and how these same maintenance pathways cause cells to respond to different stressors with apoptosis, senescence and repair. In this article, we review the theories of apoptosis, senescence and cell repair within the context of their role in the normal aging process.


Aging Inflammation Apoptosis Immunosenescence Auto-inflammatory diseases 


Compliance with Ethical Standards

Conflict of Interest

Nicolas Coronel Restrepo declares that he has no conflict of interest. Fabio Bonilla Abadía declares that he has no conflict of interest. Andres Agualimpia declares that he has no conflict of interest. Andrés F. Echeverri declares that he has no conflict of interest. Fabio E. Ospina declares that he has no conflict of interest. Carlos A. Cañas declares that he has no conflict of interest. Gabriel J. Tobón declares that he has no conflict of interest.

Informed Consent

As there is no person or personal data appearing in the paper, there is no one from whom a permission should be obtained in order to publish personal data.

Ethical Treatment of Experimental Subjects (Animal and Human)

This article does not contain any studies, performed by any of the authors, with human or animal participants and, as such, did not require ethical approval.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Nicolas Coronel-Restrepo
    • 1
  • Fabio Bonilla-Abadía
    • 2
  • Andres Agualimpia
    • 2
  • Andrés F. Echeverri
    • 2
  • Fabio E. Ospina
    • 2
    • 3
  • Carlos A. Cañas
    • 2
  • Gabriel J. Tobón
    • 2
    • 4
  1. 1.Internal Medicine Unit, Fundación Valle del LiliCES University Medical SchoolCaliColombia
  2. 2.Rheumatology Unit, Fundación Valle del Lili, Medical School CaliICESI UniversityCaliColombia
  3. 3.Instituto de Investigaciones ClínicasFundación Valle del LiliCaliColombia
  4. 4.Laboratory of ImmunologyFundación Valle del LiliCaliColombia

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