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A Novel ALK–THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review

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Abstract

Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm most frequently seen in the abdomino-pelvic region and lungs of children and young adults. Laryngeal tumors are rare. We present a case of a 23-year-old patient with a 5 month history of laryngitis and aphonia unresolved by corticotherapy. Laryngoscopy revealed a small, non-ulcerated, subepithelial, polypoid mass arising from the right vocal cord. The diagnosis of IMT with ALK expression was supported by histopathologic and molecular analysis. The THBS1 fusion partner was identified by RNA-sequencing analysis for the first time in a laryngeal IMT. This fusion partner has only been identified in six uterine IMTs thus far. Conservative excision of the lesion yielded excellent functional results for the patient. The voice was preserved and no recurrences were seen after 6 months of follow-up.

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Acknowledgment

The authors would like to thank Dr. Marie Karanian for the RNA-sequencing analysis (Department of Pathology, Centre Leon Berard, Lyon).

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Authors and Affiliations

  1. Department of Pathology, CHU Montpellier, Montpellier, France

    Abderrahim Elktaibi & Valérie Costes Martineau

  2. Department of Pathology, CHU Lyon, Lyon, France

    Nazim Benzerdjeb & Juliet Tantot

  3. Department of Radiology, CHU Lyon, Lyon, France

    Fatima Ameur

  4. Department of Surgery, CHU Lyon, Lyon, France

    Clementine Daveau

Authors
  1. Abderrahim Elktaibi
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  2. Nazim Benzerdjeb
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  3. Fatima Ameur
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  4. Clementine Daveau
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  5. Juliet Tantot
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  6. Valérie Costes Martineau
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Correspondence to Abderrahim Elktaibi.

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Elktaibi, A., Benzerdjeb, N., Ameur, F. et al. A Novel ALK–THBS1 Fusion in a Laryngeal Inflammatory Myofibroblastic Tumour: A Case Report and Literature Review. Head and Neck Pathol 14, 454–458 (2020). https://doi.org/10.1007/s12105-019-01061-x

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  • DOI: https://doi.org/10.1007/s12105-019-01061-x

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