Schwannoma-Like Pleomorphic Adenoma: Two Cases and a Review of the Literature

  • Stephen H. RothEmail author
  • William C. Faquin
  • Cecilia Gimenez
  • Bhumika Vadalia
  • Douglas K. Frank
  • Jian Yi Li
Original Paper


Schwannoma-like pleomorphic adenoma is a rare variant of the common benign salivary neoplasm, pleomorphic adenoma. This entity’s cytomorphology closely mimics a schwannoma, potentially making a diagnosis of cytologic preparations or of surgical specimens a challenge. To the best of our knowledge, there are only six previous reports of schwannoma-like pleomorphic adenoma with eight total cases in the English language literature prior to the addition of the two cases detailed in this report. Our report includes what we believe to be the first documented case of this entity occurring in the submandibular gland. One of our cases occurred in the submandibular gland of a 90-year-old woman and the other occurred in the left parotid gland of a 40-year-old woman. We also examine the diagnostic considerations used to differentiate these two entities.


Pleomorphic adenoma Schwannoma Benign Spindle cell lesion Fine-needle aspirate Cytopathology Parotid gland Submandibular gland Schwannoma-like pleomorphic adenoma 



The authors would like to acknowledge Dr. Kasturi Das, MD for her assistance with the cytopathologic interpretation of these cases.

Compliance with ethical standards

Conflict of interest

The authors have nothing to disclose.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Oral Pathology, Department of Dental Medicine, Long Island Jewish Medical CenterDonald and Barbara Zucker School of Medicine at Hofstra/Northwell HealthHyde ParkUSA
  2. 2.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical CenterDonald and Barbara Zucker School of Medicine at Hofstra/Northwell HealthNew Hyde ParkUSA
  4. 4.Division of Head and Neck Surgery, Department of Otolaryngology, Long Island Jewish Medical CenterDonald and Barbara Zucker School of Medicine at Hofstra/Norhtwell HealthNew Hyde ParkUSA

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