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Salivary Duct Carcinoma of the Parotid Gland Originating from an Epithelial-Myoepithelial Carcinoma: Report of a Rare Case

  • Yuichiro Hamamoto
  • Hiroshi Harada
  • Motoyuki Suzuki
  • Takashi Fujii
  • Shin-ichi NakatsukaEmail author
Case Report
  • 32 Downloads

Abstract

Salivary duct carcinoma (SDC) is a high-grade carcinoma with poor prognosis, especially among various salivary carcinomas. In this study, we report a rare case of SDC of the parotid gland originating from an epithelial-myoepithelial carcinoma (EMC). A 71-year-old Japanese man presented with swelling of the right parotid region and a right facial nerve paralysis for 10 months. He underwent extended total parotidectomy and chemoradiotherapy after the surgery. Histologically, a major part of the tumor was an androgen receptor (AR)-positive, human epidermal growth factor receptor 2 (HER2)-positive, gross cystic disease fluid protein-15 (GCDFP-15)-positive SDC, with a focus of a typical EMC component at the periphery of the lesion. In the transitional area of the two components, inner ductal cells of double-layered ducts showed similar morphology and immunophenotype to SDC. These findings suggest that SDC originated from the inner ductal cells of EMC. Because the tumor included an EMC as a low-grade carcinoma and an SDC as a high-grade carcinoma, we can consider our case as a dedifferentiated carcinoma as well as a hybrid tumor.

Keywords

Salivary duct carcinoma Parotid gland Epithelial-myoepithelial carcinoma Dedifferentiation 

Notes

Acknowledgements

The authors thank all medical technologists (Osaka International Cancer Institute) for their technical assistance and Editage (http://www.editage.jp) for English language editing. No funding obtained.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Adel K, et al. WHO classification of head and neck tumours. Lyon: IARC Press; 2017. pp. 173–5.Google Scholar
  2. 2.
    Seifert G, et al. Hybrid tumors of salivary glands. Definition and classification of five rare cases. Eur J Cancer B. 1996;32:251–9.CrossRefGoogle Scholar
  3. 3.
    Croitoru CM, et al. Hybrid carcinomas of the salivary glands. Report of 4 cases and review of the literature. Arch Pathol Lab Med. 1999;123:698–702.Google Scholar
  4. 4.
    Zardawi IM. Hybrid carcinoma of the salivary gland. Histopathology. 2000;37:283–4.CrossRefGoogle Scholar
  5. 5.
    Nagao T, et al. Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic immunohistochemical, and p53 gene alteration analysis. Mod Pathol. 2002;15:724–33.CrossRefGoogle Scholar
  6. 6.
    Kainuma K, et al. Hybrid carcinoma of the parotid gland: report of a case (epithelial-myoepithelial carcinoma and salivary duct carcinoma) and review of the literature. Acta Otolaryngol. 2010;130:185–9.CrossRefGoogle Scholar
  7. 7.
    Chênevert J, et al. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25:919–29.CrossRefGoogle Scholar
  8. 8.
    Seethala RR, et al. New variants of epithelial-myoepithelial carcinoma: oncocytic-seba-ceous and apocrine. Arch Pathol Lab Med. 2009;133:950–9.Google Scholar
  9. 9.
    Seethala RR. Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor. Head Neck Pathol. 2013;7:77–84.CrossRefGoogle Scholar
  10. 10.
    Gnepp DR, et al. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic Surgical Pathology of the Head and Neck. Philadelphia: WB Saunders Co.; 2000. pp. 325–430.Google Scholar
  11. 11.
    Ballestin C, et al. Combined acinic cell mucoepidermoid carcinoma of the parotid gland. Report of a case with immunohistochemical study. APMIS. 1996;104:99–102.CrossRefGoogle Scholar
  12. 12.
    Chetty R, et al. Hybrid carcinomas of the salivary glands. Arch Pathol Lab Med. 2000;124:494–6.Google Scholar
  13. 13.
    Piana S, et al. Epstein-Barr-positive lymphoepithelial carcinoma and epi-myoepithelial cell carcinoma of the parotid gland: a hitherto unreported example of hybrid tumor. Virchows Arch. 2004;445:425–8.CrossRefGoogle Scholar
  14. 14.
    Murphy JG, et al. Salivary hybrid tumor: adenoid cystic carcinoma and basal cell adenocarcinoma. Virchows Arch. 2006;448:236–8.CrossRefGoogle Scholar
  15. 15.
    Atay G, et al. Hybrid carcinoma of the parotid gland: ductal carcinoma and myoepithelial carcinoma. Kulak Burun Bogaz Ihtis Derg. 2014;24:46–9.CrossRefGoogle Scholar
  16. 16.
    Sabri A, et al. Hybrid tumor of the parotid gland: a case report and review of the literature. Case Rep Otolaryngol. 2015;2015:192453.Google Scholar
  17. 17.
    Katoh M, et al. An orderly retreat: dedifferentiation is a regulated process. Proc Natl Acad Sci USA. 2004;101:7005–10.CrossRefGoogle Scholar
  18. 18.
    Gnepp DR, et al. Salivary and lacrimal glands. In: Gnepp DR, editor. Diagnostic Surgical Pathology of the Head and Neck. 2nd ed. Philadelphia: Saunders; 2009. pp. 413–562.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yuichiro Hamamoto
    • 1
  • Hiroshi Harada
    • 1
    • 2
  • Motoyuki Suzuki
    • 3
  • Takashi Fujii
    • 4
  • Shin-ichi Nakatsuka
    • 1
    Email author
  1. 1.Department of Diagnostic Pathology and CytologyOsaka International Cancer InstituteOsakaJapan
  2. 2.Department of Diagnostic PathologySeichokai Fuchu HospitalIzumi-CityJapan
  3. 3.Department of Otorhinolaryngology-Head and Neck SurgeryOsaka University Graduate School of MedicineSuitaJapan
  4. 4.Department of Head and Neck SurgeryOsaka International Cancer InstituteOsakaJapan

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