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Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation


A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1–3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET–CT scans.

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Correspondence to Fredrik Petersson.

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Petersson, F. Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation. Head and Neck Pathol 14, 195–198 (2020).

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  • Nasopharynx
  • Carcinoma
  • Adenocarcinoma
  • Epstein–Barr virus