Head and Neck Pathology

, Volume 13, Issue 4, pp 727–730 | Cite as

Ciliated HPV-Related Carcinoma: A Diagnostic Challenge on Frozen Section

  • Pooja NavaleEmail author
  • Eric M. Genden
  • Mary Beth Beasley
Case Report


Oropharyngeal squamous cell carcinomas associated with high risk HPV show a wide morphological spectrum, including papillary, adenosquamous, lymphoepithelioma-like and sarcomatoid. We report an interesting case of ciliated HPV-related carcinoma arising from tonsillar tissue in a 55-year-old man which was associated with HPV33. This rare variant has been described in only a handful of cases in the literature, and to our knowledge this is the first case specifically associated with HPV33. The presence of cilia is a potential diagnostic problem as it has been traditionally considered a feature of benignancy, and could pose a particular challenge on frozen section. The diagnostic challenges, differential diagnosis of this tumor and the association with HPV33 are discussed.


Ciliated HPV-related Mimicker HPV33 



This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with Ethical Standards

Conflict of interest

The authors declare that there is no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyNew YorkUSA
  2. 2.Department of Otolaryngology-Head and Neck SurgeryIcahn School of Medicine at Mount SinaiNew YorkUSA

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