Head and Neck Pathology

, Volume 13, Issue 4, pp 677–680 | Cite as

Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!

  • Vikram Singh
  • Kirti GuptaEmail author
  • Pravin Salunke
  • Sivashanmugam S. Dhandapani
Sine qua non Radiology-Pathology


Null cell adenoma is composed of adenohypophyseal cells that show no evidence of any specific cell type differentiation by immunohistochemistry or transcription factors like pituitary-specific positive transcription factor 1 and steroidogenic factor 1. Though rare, pituitary ependymoma and germinoma are also known to occur at sellar region and in such instances, it is challenging to differentiate them from a pituitary null cell adenoma featuring papillary architecture and perivascular pseudo-rosettes. We describe a case of an elderly diabetic lady presenting with headache and blurring of vision for past 3 months due to a sellar tumour. The histology was diagnostically challenging with notable presence of numerous perivascular pseudo-rosettes and negative immunoreactivity for all pituitary hormones. The differential diagnosis and importance of ancillary techniques is discussed.


Null cell adenoma Pseudo-rosettes Sellar tumour Pituitary tumor 


Compliance with Ethical Standards

Conflict of interest

We do not have any financial disclosures and no conflicts of interests.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of HistopathologyPost Graduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia
  2. 2.Department of NeurosurgeryPost Graduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

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