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Head and Neck Pathology

, Volume 13, Issue 4, pp 722–726 | Cite as

Laryngeal Epstein–Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child

  • Ciro Dantas SoaresEmail author
  • Roman Carlos
  • Juan Pablo Díaz Molina
  • Thayná Melo de Lima Morais
  • Oslei Paes de Almeida
Case Report

Abstract

Smooth muscle tumors associated with Epstein–Barr virus infections (EBV–SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for α-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author’s knowledge, this is the first literature-reported case of laryngeal EBV–SMT occurring in an undernourished child.

Keywords

Epstein–Barr virus infections/pathology Smooth muscle tumor/pathology Pediatric tumors 

Notes

Funding

This work was supported by São Paulo Research Foundation (FAPESP), Grant Number #2015/25905-1.

Compliance with Ethical Standards

Conflict of interest

The authors declare no potential conflicts of interest related to this case report, to this study’s authorship, and/or to its publication.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Oral Pathology, Piracicaba Dental SchoolUniversity of Campinas (UNICAMP)PiracicabaBrazil
  2. 2.Centro Clínico de Cabeza y Cuello/Hospital Herrera LlerandiCiudad de GuatemalaGuatemala

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