Head and Neck Pathology

, Volume 13, Issue 4, pp 718–721 | Cite as

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

  • Neetha Santosh
  • Kristin K. McNamara
  • John R. Kalmar
  • O. Hans IwenofuEmail author
Case Report


Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.


Calcifying epithelial odontogenic tumor Anterior maxilla Non-calcifying variant Langerhans cells 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Neetha Santosh
    • 1
    • 2
  • Kristin K. McNamara
    • 1
  • John R. Kalmar
    • 1
  • O. Hans Iwenofu
    • 3
    Email author
  1. 1.Divison of Oral and Maxillofacial Pathology and RadiologyThe Ohio State University College of DentistryColumbusUSA
  2. 2.Department of Oral Pathology, Radiology and MedicineIndiana University School of DentistryIndianapolisUSA
  3. 3.Department of Pathology & Laboratory MedicineThe Ohio State University Wexner Medical CenterColumbusUSA

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