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Head and Neck Pathology

, Volume 13, Issue 4, pp 671–676 | Cite as

Embryonal Rhabdomyosarcoma (Botryoid Subtype) Affecting the Buccal Mucosa

  • John Lennon Silva CunhaEmail author
  • Francisco De Assis Almeida Lima-Júnior
  • Wilson Déda Gonçalves Júnior
  • Thiago De Santana Santos
  • Ericka Janine Dantas Da Silveira
  • Silvia Ferreira De Sousa
  • Ricardo Luiz Cavalcanti De Albuquerque-Júnior
Sine qua non Clinicopathologic Correlation
  • 185 Downloads

Abstract

Rhabdomyosarcoma (RMS) is a rare oral malignant soft tissue tumor whose pathological features may influence the clinical behavior, treatment and prognosis of the lesion. We report a case of a 13-year-old female patient, presenting an asymptomatic polypoid swelling in the left buccal mucosa that was approximately 2.5 cm in diameter and 3 months evolution. The presumptive diagnosis was fibrous hyperplasia and an excisional biopsy was carried out. Pathologic analysis revealed proliferation of predominantly ovoid cells, with eosinophilic cytoplasm and pleomorphic nuclei, arranged in subepithelial cambium layer. The mucosal surface presented a papillary–verrucous appearance. Immunohistochemical analysis revealed intense positivity for desmin, myogenin and Ki-67. The diagnosis was of embryonal RMS (botryoid variant). The patient was subjected to complementary chemotherapy and radiotherapy, with no evidence of recurrence or metastatic disease after 12 months follow-up. A discussion on the clinical, histopathological, immunohistochemical and therapeutic aspects of botryoid RMS will be provided.

Keywords

Pediatric rhabdomyosarcoma Rhabdomyosarcoma Head and neck neoplasms Radiotherapy 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • John Lennon Silva Cunha
    • 1
    Email author
  • Francisco De Assis Almeida Lima-Júnior
    • 2
  • Wilson Déda Gonçalves Júnior
    • 2
  • Thiago De Santana Santos
    • 2
  • Ericka Janine Dantas Da Silveira
    • 3
  • Silvia Ferreira De Sousa
    • 4
  • Ricardo Luiz Cavalcanti De Albuquerque-Júnior
    • 1
  1. 1.Laboratory of Morphology and Experimental Pathology, Institute of Technology and ResearchTiradentes UniversityAracajuBrazil
  2. 2.Department of DentistryTiradentes UniversityAracajuBrazil
  3. 3.Department of Dentistry, Postgraduate Program in Oral PathologyFederal University of Rio Grande do NorteNatalBrazil
  4. 4.Department of DentistryFederal University of SergipeAracajuBrazil

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