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Head and Neck Pathology

, Volume 13, Issue 4, pp 711–717 | Cite as

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

  • Ricardo Natã Fonseca Silva
  • Elismauro Francisco Mendonça
  • Aline Carvalho Batista
  • Rita de Cássia Gonçalves Alencar
  • Ricardo Alves Mesquita
  • Nadia Lago CostaEmail author
Case Report

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin’s lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region. Preoperative examination and incisional biopsy were performed. Immunohistochemistry was applied to confirm the diagnosis of THRBCL in the jaw. The treatment consisted of CHOP therapy and radiotherapy. After complete tumor remission following initial treatment, additional sites of the disease appeared in the lung, abdomen and long bones. The patient died within 2 months. THRLBCL is an uncommon and aggressive malignant neoplasm that can involve the jaws, mimicking a periapical disease.

Keywords

Jaw Lymphoma Non-hodgkin Lymphoma Large B-cell Diffuse Periapical diseases 

Notes

Funding

The first author declares no funding grants were received or otherwise associated with the production of this paper.

Compliance with Ethical Standards

Conflict of interest

All authors named in this case report declare that they have no conflict of interest.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ricardo Natã Fonseca Silva
    • 1
  • Elismauro Francisco Mendonça
    • 1
    • 2
  • Aline Carvalho Batista
    • 1
  • Rita de Cássia Gonçalves Alencar
    • 3
  • Ricardo Alves Mesquita
    • 4
  • Nadia Lago Costa
    • 1
    Email author
  1. 1.Department of Stomathology (Oral Pathology), School of DentistryFederal University of GoiasGoiâniaBrazil
  2. 2.Division of Head and Neck, Araújo Jorge HospitalAssociation of Cancer Combat of GoiásGoiâniaBrazil
  3. 3.Laboratory of Pathology, Araújo Jorge HospitalAssociation of Cancer Combat of GoiásGoiâniaBrazil
  4. 4.Department of Oral Surgery and Pathology, School of DentistryFederal University of Minas GeraisBelo HorizonteBrazil

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