Head and Neck Pathology

, Volume 13, Issue 4, pp 692–698 | Cite as

Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature

  • Deepak Pandiar
  • Sangeetha K. NayanarEmail author
  • Basavaraj Ankalkoti
  • Sajith Babu
Case Report


Basaloid squamous cell carcinoma with spindle cell component is an uncommon aggressive variety of squamous cell carcinoma with only a few reported cases in literature. Histologically a combination of basaloid squamous cell carcinoma and spindle cell squamous cell carcinoma is appreciated and immunohistochemistry serves a role in differentiation from malignant neoplasms of salivary gland or neuro-endocrine origin. Prime treatment modality is combination of surgery and external beam radiotherapy. A case of basaloid squamous cell carcinoma with proliferation of bizarre mesenchymal component is being reported here with an updated literature review.


Basaloid Epithelial mesenchymal transition Glottis Spindle cell 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Statement

The manuscript is based on the total laryngectomy specimen received in our department with no additional psychological, physical and financial burden for the patient.


  1. 1.
    Wain SL, Kier R, Vollmer RT, Bossen EH. Basaloid squamous cell carcinoma of the tongue, hypopharynx and larynx. Report of 10 cases. Hum Pathol. 1986;17:1158–66.CrossRefGoogle Scholar
  2. 2.
    Muller S, Barnes L. Basaloid squamous cell carcinoma of the head and neck with a spindle cell component: an unusual histologic variant. Arch Pathol Lab Med. 1995;119:181–2.Google Scholar
  3. 3.
    Wieneke JA, Thompson LDR, Wenig BM. Basaloid squamous cell carcinoma of the sinonasal tract. Cancer. 1999;85:841–54.CrossRefGoogle Scholar
  4. 4.
    Kimura T, Mukai M, Shiotani A, et al. Basaloid squamous cell carcinoma of the hypopharynx with extensive spindle cell component exhibiting a pedonculated polypoid mass. Arch Pathol Lab Med. 2005;129:e94–6.Google Scholar
  5. 5.
    Altrabulsi B, Carrizo F, Luna MA. Spindle cell squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases. Ann Diagn Pathol. 2006;10:149–53.CrossRefGoogle Scholar
  6. 6.
    Lavialle-Guillotreau V, Uro-Costea E, Patelli A, Belvèzec P, Delisle MB. Basaloid squamous carcinoma with a spindle cell component and osseous metaplasia presenting as a polyp of the hypopharynx. Annales de pathologie 2011;31:214–17.CrossRefGoogle Scholar
  7. 7.
    Wollina U, Koch A, Schönlebe J, Tchernev G. Carcinosarcoma of skin (sarcomatoid carcinoma)—a rare non-melanoma skin cancer (case review). Georgian Med News. 2017;(263):7–10.Google Scholar
  8. 8.
    Maeda D, Fujii A, Yamaguchi K. Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: The first report of an unusual biphasic tumor of the ureter Jpn. J Clin Oncol. 2007;37:878–83.Google Scholar
  9. 9.
    Hickman RA, Bradshaw AD, Cassai N, Neto AG, Zhou D, Fu T, Lee P, Pei Z, Wieczorek R. A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: an immunohistochemical, molecular and ultrastructural study. Papillomavirus Res 2016;2:164–6.CrossRefGoogle Scholar
  10. 10.
    El-Mofty SK. Human papilloma virus-related head and neck squamous cell carcinoma variants. Semin Diagn Pathol. 2015;32(1):23–31.CrossRefGoogle Scholar
  11. 11.
    Chernock RD, Lewis JS Jr, Zhang Q, El-Mofty SK. Human papillomavirus positive basaloid squamous cell carcinoma of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Human Pathol. 2010;41:1016–23.Google Scholar
  12. 12.
    Begum S, Westra WH. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32:1044–50.CrossRefGoogle Scholar
  13. 13.
    Thomas VT, Hinson S, Konduri K. Epithelial-mesenchymal transition in pulmonary carcinosarcoma: case report and literature review. Ther Adv Med Oncol. 2012;4(1):31–7.CrossRefGoogle Scholar
  14. 14.
    Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest. 2009;119:1438–49.CrossRefGoogle Scholar
  15. 15.
    Bukholm IK, Nesland JM, Borresen-Dale AL. Re-expression of E-cadherin, alphacatenin and beta-catenin, but not of gammacatenin, in metastatic tissue from breast cancer patients. J Pathol. 2000;190:15–9.CrossRefGoogle Scholar
  16. 16.
    Mareel M, Brack M, Frans VR. Cancer metastasis: negative regulation by an invasion-suppressor complex. Cancer Detect Prev. 1995;19:451–64.PubMedGoogle Scholar
  17. 17.
    Ishibashi N, Maebayashi T, Aizawa T, Sakaguchi M, Nishimaki H, Masuda Masuda SS. Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer. Radiat Oncol. 2017;12:16.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Deepak Pandiar
    • 1
  • Sangeetha K. Nayanar
    • 1
    Email author
  • Basavaraj Ankalkoti
    • 2
  • Sajith Babu
    • 2
  1. 1.Department of Clinical Laboratory Services and Translational ResearchMalabar Cancer CenterThalasseryIndia
  2. 2.Department of Surgical OncologyMalabar Cancer CenterThalasseryIndia

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