Head and Neck Pathology

, Volume 13, Issue 4, pp 656–660 | Cite as

Head and Neck Sinus Histiocytosis with Massive Lymphadenopathy Radiology–Pathology Correlation

  • Vincent Cracolici
  • Sandeep Gurbuxani
  • Daniel T. GinatEmail author
Sine qua non Radiology-Pathology


Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare, benign type of non-Langerhans cell histiocytosis. The radiological findings are often nonspecific, potentially mimicking malignancies. The diagnosis is ultimately made based on pathology, in which the lymph nodes are characterized by a dilated subcapsular sinus filled with histiocytes that can exhibit emperipolesis. Immunohistochemically, the histiocytes are variably CD68 positive and reliably negative for CD1a. The features of head and neck sinus histiocytosis with massive lymphadenopathy are exemplified in this radiology-pathology correlation sine qua non article.


Sinus histiocytosis with massive lymphadenopathy Radiology Pathology 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Vincent Cracolici
    • 1
  • Sandeep Gurbuxani
    • 1
  • Daniel T. Ginat
    • 2
    Email author
  1. 1.Department of PathologyUniversity of ChicagoChicagoUSA
  2. 2.Department of RadiologyUniversity of ChicagoChicagoUSA

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