Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology

  • Giap Hean Goh
  • Thomas Choudary Putti
  • Raymond Ngo
  • Abbas Agaimy
  • Fredrik PeterssonEmail author
Case Report


We present a case of a primary 2.5 cm pleomorphic lipoma of the right parotid gland with prominent myxoid change which on FNA displayed features that mimicked a carcinoma or sarcoma ex pleomorphic adenoma. The patient was a 79 year old man with no oncological history or tumor elsewhere. On immunohistochemistry the neoplastic cells strongly expressed CD34. There was no expression of retinoblastoma protein, smooth muscle actin, S100-protein or cytokeratins (AE1/3 and CAM5.2). The Ki-67 proliferation index was low (< 2%). Fluorescence in situ hybridization was negative for MDM2 gene amplification.


Pleomorphic lipoma Parotid gland Carcinoma ex pleomorphic adenoma Carcinosarcoma ex pleomorphic adenoma Fine needle aspiration cytology 


Compliance with Ethical Standards

Conflict of interest

The authors state that there are no conflicts of interest to disclose.

Ethical Approval

It is our institution’s policy not to require formal ethical approval for reports on up to two patients.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PathologyNational University HospitalSingaporeSingapore
  2. 2.Department of Otolaryngology - Head and Neck Surgery (ENT)National University HospitalSingaporeSingapore
  3. 3.Institute of Pathology, University Hospital ErlangenFriedrich Alexander University (FAU)ErlangenGermany
  4. 4.Department of PathologyNational University Health SystemSingaporeSingapore

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