Non-infectious Granulomatous Lesions of the Orofacial Region

  • Susan Müller
Proceeding of the North American Society of Head and Neck Pathology Companion Meeting, March 17, 2019, National Harbor, MD


Granulomatous lesions of the orofacial region are a heterogeneous group of disorders characterized by a granulomatous reaction to a variety of stimuli. Infectious agents, foreign material, systemic inflammation and metabolic disorders can all be associated with granulomatous inflammation. In the orofacial region primary causes of granulomatosis include foreign body reaction, delayed hypersensitivity to topical agents and idiopathic orofacial granulomatosis. Secondary causes of granulomas include infectious agents, sarcoid, and Crohn disease. For this review, infectious causes of orofacial granulomatosis (OFG) including bacteria, parasites and fungi will not be discussed.


Orofacial granulomatosis Sarcoid Crohn disease Cheilitis granulomatosis Melkersson Rosenthal 



No funding was required for this study.

Compliance with Ethical Standards

Conflict of interest

The author declares they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Atlanta Oral Pathology, Emory Decatur HospitalEmory University School of MedicineDecaturUSA

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