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Non-infectious Granulomatous Lesions of the Orofacial Region

  • Susan Müller
Proceeding of the North American Society of Head and Neck Pathology Companion Meeting, March 17, 2019, National Harbor, MD
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Abstract

Granulomatous lesions of the orofacial region are a heterogeneous group of disorders characterized by a granulomatous reaction to a variety of stimuli. Infectious agents, foreign material, systemic inflammation and metabolic disorders can all be associated with granulomatous inflammation. In the orofacial region primary causes of granulomatosis include foreign body reaction, delayed hypersensitivity to topical agents and idiopathic orofacial granulomatosis. Secondary causes of granulomas include infectious agents, sarcoid, and Crohn disease. For this review, infectious causes of orofacial granulomatosis (OFG) including bacteria, parasites and fungi will not be discussed.

Keywords

Orofacial granulomatosis Sarcoid Crohn disease Cheilitis granulomatosis Melkersson Rosenthal 

Notes

Funding

No funding was required for this study.

Compliance with Ethical Standards

Conflict of interest

The author declares they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Al-Hamad A, Porter S, Fedele S. Orofacial granulomatosis. Dermatol Clin. 2015;33(3):433–46.Google Scholar
  2. 2.
    Troiano G, Dioguardi M, Giannatempo G, et al. Orofacial granulomatosis: clinical signs of different pathologies. Med Princ Pract. 2015;24(2):117–22.Google Scholar
  3. 3.
    Miest R, Bruce A, Rogers RS. Orofacial granulomatosis. Clin Dermatol. 2016;34(4):505–13.Google Scholar
  4. 4.
    Grave B, McCullough M, Wiesenfeld D. Orofacial granulomatosis—a 20-year review. Oral Dis. 2009;15(1):46–51.Google Scholar
  5. 5.
    Ito T, Connett JM, Kunkel SL, Matsukawa A. The linkage of innate and adaptive immune response during granulomatous development. Front Immunol. 2013;31:4–10.Google Scholar
  6. 6.
    Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E. Cutaneous granulomatosis: a comprehensive review. Clin Rev Allergy Immunol. 2018;54(1):131–46.Google Scholar
  7. 7.
    Shah KK, Pritt BS, Alexander MP. Histopathologic review of granulomatous inflammation. J Clin Tuberc Other Mycobact Dis. 2017;7:1–12.Google Scholar
  8. 8.
    Wick MR. Granulomatous & histiocytic dermatitides. Semin Diagn Pathol. 2017;34(3):301–311.Google Scholar
  9. 9.
    Fitzpatrick L, Healy CM, McCartan BE, et al. Patch testing for food-associated allergies in orofacial granulomatosis. J Oral Pathol Med. 2011;40(1):10–3.Google Scholar
  10. 10.
    Miest RY, Bruce AJ, Comfere NI, et al. A diagnostic approach to recurrent orofacial swelling: a retrospective study of 104 patients. Mayo Clin Proc. 2017;92(7):1053–1060.Google Scholar
  11. 11.
    Mignogna MD, Fedele S, Lo Russo L, Lo Muzio L. The multiform and variable patterns of onset of orofacial granulomatosis. J Oral Pathol Med. 2003;32(4):200–5.Google Scholar
  12. 12.
    Gale G, Sigurdsson GV, Östman S, et al. Does Crohn’s disease with concomitant orofacial granulomatosis represent a distinctive disease subtype? Inflamm Bowel Dis. 2016;22(5):1071–7.Google Scholar
  13. 13.
    Marcoval J, Penín RM. Histopathological features of orofacial granulomatosis. Am J Dermatopathol. 2016;38(3):194–200.Google Scholar
  14. 14.
    Wiesenfeld D, Ferguson MM, Mitchell DN, et al. Oro-facial granulomatosis—a clinical and pathological analysis. Q J Med. 1985;54(213):101–13.Google Scholar
  15. 15.
    Melkersson E. Ett fall av recidiverande facialispares i samband med ett angioneurotiskt dem. Vol. 90. Stockholm: Hygiea; 1928. pp. 737e41.Google Scholar
  16. 16.
    Critchlow WA, Chang D. Cheilitis granulomatosa: a review. Head Neck Pathol. 2014;8(2):209–13.Google Scholar
  17. 17.
    Rogers RS. Granulomatous cheilitis, Melkersson–Rosenthal syndrome, and orofacial granulomatosis. Arch Dermatol. 2000;136(12):1557–8. rd .Google Scholar
  18. 18.
    Al Johani K, Moles DR, Hodgson T, Porter SR, Fedele S. Onset and progression of clinical manifestations of orofacial granulomatosis. Oral Dis. 2009;15(3):214–9.Google Scholar
  19. 19.
    Cocuroccia B, Gubinelli E, Annessi G, Zambruno G, Girolomoni G. Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson–Rosenthal syndrome. J Eur Acad Dermatol Venereol. 2005;19(1):107–11.Google Scholar
  20. 20.
    Rivera-Serrano CM, Man LX, Klein S, Schaitkin BM. Melkersson–Rosenthal syndrome: a facial nerve center perspective. J Plast Reconstr Aesthet Surg. 2014;67(8):1050–4.Google Scholar
  21. 21.
    Kanerva M, Moilanen K, Virolainen S, Vaheri A, Pitkäranta A. Melkersson–Rosenthal syndrome. Otolaryngol Head Neck Surg. 2008;138(2):246–51.Google Scholar
  22. 22.
    Lazzerini M, Martelossi S, Cont G, et al. Orofacial granulomatosis in children: think about Crohn’s disease. Dig Liver Dis. 2015;47(4):338–41.Google Scholar
  23. 23.
    Lazzerini M, Bramuzzo M, Ventura A. Association between orofacial granulomatosis and Crohn’s disease in children: systematic review. World J Gastroenterol. 2014;20(23):7497–504.Google Scholar
  24. 24.
    Bharti R, Wadhwani KK, Tikku AP, Chandra A. Dental amalgam: an update. J Conserv Dent. 2010;13(4):204–8.Google Scholar
  25. 25.
    Telang LA. Body art: intraoral tattoos. Br Dent J. 2015;218(4):212–3.Google Scholar
  26. 26.
    Haneke E. Adverse effects of fillers. Dermatol Ther. 2018;5:e12676.  https://doi.org/10.1111/dth.12676.Google Scholar
  27. 27.
    Requena L, Requena C, Christensen L, et al. Adverse reactions to injectable soft tissue fillers. J Am Acad Dermatol. 2011;64(1):1–34. quiz 35–6.Google Scholar
  28. 28.
    Eversole R, Tran K, Hansen D, Campbell J. Lip augmentation dermal filler reactions, histopathologic features. Head Neck Pathol. 2013;7(3):241–9.Google Scholar
  29. 29.
    Shahrabi-Farahani S, Lerman MA, Noonan V, Kabani S, Woo SB. Granulomatous foreign body reaction to dermal cosmetic fillers with intraoral migration. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(1):105–10.Google Scholar
  30. 30.
    Requena C, Requena L, Alegre V, et al. Adverse reaction to silicone simulating orofacial granulomatosis. J Eur Acad Dermatol Venereol. 2015;29(5):998–1001.Google Scholar
  31. 31.
    Feuerstein JD, Cheifetz AS. Crohn disease: epidemiology, diagnosis, and management. Mayo Clin Proc. 2017;92(7):1088–1103.Google Scholar
  32. 32.
    Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54.e42.Google Scholar
  33. 33.
    Gajendran M, Loganathan P, Catinella AP, Hashash JG. A comprehensive review and update on Crohn’s disease. Dis Mon. 2018;64(2):20–57.Google Scholar
  34. 34.
    Eckel A, Lee D, Deutsch G, Maxin A, Oda D. Oral manifestations as the first presenting sign of Crohn’s disease in a pediatric patient. J Clin Exp Dent. 2017;9(7):e934–8.Google Scholar
  35. 35.
    Woo VL. Oral manifestations of Crohn’s disease: a case report and review of the literature. Case Rep Dent. 2015;2015:830472.Google Scholar
  36. 36.
    Sanderson J, Nunes C, Escudier M, et al. Oro-facial granulomatosis: Crohn’s disease or a new inflammatory bowel disease? Inflamm Bowel Dis. 2005;11(9):840–6.Google Scholar
  37. 37.
    Hoekman DR, Diederen K, Benninga MA. Crohn’s disease with orofacial granulomatosis is a distinct disease subtype, or is it? Inflamm Bowel Dis. 2016;22(7):E23.Google Scholar
  38. 38.
    Gale G, Östman S, Rekabdar E, et al. Characterisation of a Swedish cohort with orofacial granulomatosis with or without Crohn’s disease. Oral Dis. 2015;21(1):e98–104.Google Scholar
  39. 39.
    Campbell H, Escudier M, Patel P, et al. Distinguishing orofacial granulomatosis from crohn’s disease: two separate disease entities? Inflamm Bowel Dis. 2011;17(10):2109–15.Google Scholar
  40. 40.
    Haaramo A, Alapulli H, Aine L, et al. Detailed Follow-up Study of Pediatric Orofacial Granulomatosis Patients. J Pediatr Gastroenterol Nutr. 2017;65(4):388–93.Google Scholar
  41. 41.
    Arkema EV, Cozier YC. Epidemiology of sarcoidosis: current findings and future directions. Ther Adv Chronic Dis. 2018;9(11):227–240.Google Scholar
  42. 42.
    Nico MM, Guimarães AL, Correa PY, Lourenço SV. Oral mucosal lesions in sarcoidosis: comparison with cutaneous lesions. Acta Derm Venereol. 2016;96(3):392–3.Google Scholar
  43. 43.
    James WE, Koutroumpakis E, Saha B, et al. Clinical features of extrapulmonary sarcoidosis without lung involvement. Chest. 2018;154(2):349–56.Google Scholar
  44. 44.
    Bouaziz A, Le Scanff J, Chapelon-Abric C, et al. Oral involvement in sarcoidosis: report of 12 cases. QJM. 2012;105(8):755–67.Google Scholar
  45. 45.
    Bargagli E, Prasse A. Sarcoidosis: a review for the internist. Intern Emerg Med. 2018;13(3):325–31.Google Scholar
  46. 46.
    Wessendorf TE, Bonella F, Costabel U. Diagnosis of sarcoidosis. Clin Rev Allergy Immunol. 2015;49(1):54–62.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Atlanta Oral Pathology, Emory Decatur HospitalEmory University School of MedicineDecaturUSA

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