Head and Neck Pathology

, Volume 12, Issue 2, pp 237–243 | Cite as

Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic Features

  • Ha Young Woo
  • Eun Chang Choi
  • Sun Och YoonEmail author
Original Paper


Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC). A recently diagnosed case of SC was included in the study as a reference sample. We performed IHC of S-100 and mammaglobin and ETV6 gene fluorescence in situ hybridization (FISH) in all cases. Seven cases were positive for both S-100 and mammaglobin, while five of the seven (71.4%) demonstrated ETV6 gene translocation by FISH. In the cases which did not co-express either S-100 or mammaglobin on IHC, ETV6 gene rearrangement was not shown on FISH. In conclusion, if a salivary gland tumor has morphologic features of SC with co-expression of S-100 and mammaglobin, ETV6 FISH can be performed to confirm the diagnosis of SC of the salivary gland.


Secretory carcinoma Salivary gland tumor S-100 Mammaglobin ETV6-NTRK3 



The study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2015R1D1A1A09059399).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest or funding to disclose.

Research Involving Human and Animal Rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

12105_2017_864_MOESM1_ESM.tif (12.6 mb)
Representative images of DOG1 immunohistochemical staining. A) Showed negative expression of DOG1 (case 6); B) Showed diffuse cytoplasmic expression of DOG1 (case 5). (TIF 12912 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of PathologyYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Department of OtorhinolaryngologyYonsei University College of MedicineSeoulRepublic of Korea

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