Head and Neck Pathology

, Volume 12, Issue 1, pp 127–130 | Cite as

Laryngotracheal Involvement in Systemic Light Chain Amyloidosis

  • Daniel T. Ginat
  • Jefree Schulte
  • Louis Portugal
  • Nicole A. Cipriani
Sine qua non Radiology-Pathology

Abstract

Laryngotracheal amyloid deposition is an uncommon manifestation of systemic light chain amyloidosis. Diagnostic imaging, such as CT, is useful for suggesting the possibility of amyloidosis and delineating the extent of the lesions for surgical management; however, the diagnosis is confirmed with the histologic finding of amorphous eosinophilic material which stains positively for Congo red and may show apple green birefringence on polarization. These features are exemplified in this sine qua non radiology-pathology correlation article.

Keywords

Amyloidosis Amyloidoma Larynx Trachea Radiology Pathology 

Notes

Aknowledgements

We are grateful for support received from the University of Chicago Office of Faculty Affairs through the Faculty Initiatives Fund for our Head and Neck Radiology-Pathology Trainee Conference, during which this case was presented.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no competing interests.

References

  1. 1.
    Ma L, Bandarchi B, Sasaki C, Levine S, Choi Y. Primary localized laryngeal amyloidosis: report of 3 cases with long-term follow-up and review of the literature. Arch Pathol Lab Med. 2005;129:215–8.PubMedGoogle Scholar
  2. 2.
    Pribitkin E, Friedman O, O’Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT. Amyloidosis of the upper aerodigestive tract. Laryngoscope. 2003;113:2095–101.CrossRefPubMedGoogle Scholar
  3. 3.
    Wechalekar AD, Gillmore JD, Hawkins PN. Systemic amyloidosis. Lancet. 2016;387:2641–54.CrossRefPubMedGoogle Scholar
  4. 4.
    Kastritis E, Dimopoulos MA. Recent advances in the management of AL Amyloidosis. Br J Haematol. 2016;172:170–86.CrossRefPubMedGoogle Scholar
  5. 5.
    Bahlis NJ, Lazarus HM. Multiple myeloma-associated AL amyloidosis: is a distinctive therapeutic approach warranted? Bone Marrow Transpl. 2006;38:7–15.CrossRefGoogle Scholar
  6. 6.
    Gilad R, Milillo P, Som PM. Severe diffuse systemic amyloidosis with involvement of the pharynx, larynx, and trachea: CT and MR findings. AJNR Am J Neuroradiol. 200;28:1557–8.Google Scholar
  7. 7.
    Parmar H, Rath T, Castillo M, Gandhi D. Imaging of focal amyloid depositions in the head, neck, and spine: amyloidoma. AJNR Am J Neuroradiol. 2010;31:1165–70.CrossRefPubMedGoogle Scholar
  8. 8.
    Becker M, Moulin G, Kurt AM, Dulgerov P, Vukanovic S, Zbären P, Marchal F, Rüfenacht DA, Terrier F. Non-squamous cell neoplasms of the larynx: radiologic-pathologic correlation. Radiographics. 1998;18:1189–209.CrossRefPubMedGoogle Scholar
  9. 9.
    Desport E, Bridoux F, Sirac C, Delbes S, Bender S, Fernandez B, Quellard N, Lacombe C, Goujon JM, Lavergne D, Abraham J, Touchard G, Fermand JP, Jaccard A; Centre national de référence pour l’amylose AL et les autres maladies par dépôts d’immunoglobulines monoclonales. Al amyloidosis. Orphanet J Rare Dis. 2012;7:54.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Dogan A. Amyloidosis: insights from proteomics. Annu Rev Pathol. 2017;12:277–304.CrossRefPubMedGoogle Scholar
  11. 11.
    Gouvêa AF, Ribeiro AC, León JE, Carlos R, de Almeida OP, Lopes MA. Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases. J Oral Pathol Med. 2012;41:178–85.CrossRefPubMedGoogle Scholar
  12. 12.
    Cipriani NA, Martin DE, Corey JP, Portugal L, Caballero N, Lester R, Anthony B, Taxy JB. The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse. Int J Surg Pathol. 2011;1:583–7.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Daniel T. Ginat
    • 1
  • Jefree Schulte
    • 2
  • Louis Portugal
    • 3
  • Nicole A. Cipriani
    • 2
  1. 1.Department of RadiologyUniversity of ChicagoChicagoUSA
  2. 2.Department of PathologyUniversity of ChicagoChicagoUSA
  3. 3.Department of Surgery, Section of OtolaryngologyUniversity of ChicagoChicagoUSA

Personalised recommendations