Nasopharyngeal Angiofibroma: A Clinical, Histopathological and Immunohistochemical Study of 42 Cases with Emphasis on Stromal Features
- 212 Downloads
Nasopharyngeal angiofibroma is a benign but aggressive tumor of unknown etiology, typically occurring in adolescent males. It is described as a rare neoplasm; however, the prevalence seems to have geographic differences. All cases referred to our head and neck clinical and pathology service were reviewed. Most of the patients presented at an advanced stage. The clinical and radiographic features are presented and discussed. Histologically, the tumor shows a highly vascular fibrous proliferation with characteristic plump, angulated and stellate cells, categorized as fibroblasts. Immunohistochemistry was performed on 42 cases to further elucidate the nature of these cells. The stromal cells expressed vimentin and factor XIIIa, the latter expressed most commonly in the giant stellate cells. Inflammation was almost exclusively present in peripheral subepithelial areas. Mast cells were abundant, even in the absence of other inflammatory cells. Lymphatics were observed principally in peripheral regions. Proliferating cells (Ki-67 reactive) were restricted to endothelial cells.
KeywordsNasopharyngeal angiofibroma Sinonasal tumor Vascular tumor Immunohistochemistry Imagenology Adolescent Males
This study was not funded.
Compliance with Ethical Standards
Conflict of interest
All authors declare they have no conflicts of interest.
All reviews performed in this study with human participants were done in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. As a retrospective review, informed consent was not required.
- 1.Prasad ML, Franchi A, Thompson LDR. Tumours of the nasopharynx: soft tissue tumours: nasopharyngeal angiofibroma. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (Eds). World health organization classification of head and neck tumours. 4th ed. Lyon, France: IARC Press; 2017. 74–75.Google Scholar
- 15.Ponti G, Losi L, Pellacani G, Rossi GB, Presutti L, Mattioli F, et al. Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). Appl Immunohistochem Mol Morphol. 2008;16(2):173–8.CrossRefPubMedGoogle Scholar
- 28.The World Bank. Data. [Internet]. Washington, DC. Available from http://data.worldbank.org/country/guatemala28. Accessed Mar 2017.
- 29.World Food Program. Guatemala. [Internet]. Rome. Available from http://www1.wfp.org/countries/guatemala. Accessed Mar 2017.