Head and Neck Pathology

, Volume 12, Issue 1, pp 44–51 | Cite as

Fibromyxoma of the Jaw: Case Report and Review of the Literature

  • Thabet Alhousami
  • Amarpreet Sabharwal
  • Shivane Gupta
  • Alfredo Aguirre
  • Etern Park
  • Jill M. Kramer
Original Paper
  • 223 Downloads

Abstract

We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses. In addition, we will provide an overview of patient management. Fibromxyoma is a benign gnathic tumor that can be locally aggressive. To ensure appropriate treatment, it is important to distinguish this neoplasm from other mimickers in which myxoid, spindle mesenchymal cell proliferation is prominent.

Keywords

Fibromyxoma Myxoma Odontogenic Mesenchymal tumor 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors do not have any relevant conflict of interests.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Hajdu SI, Vadmal M. A note from history: landmarks in history of cancer, Part 6. Cancer. 2013;119(23):4058–82.CrossRefPubMedGoogle Scholar
  2. 2.
    Thoma KH, Goldman HM. Central myxoma of the jaw. Am J Orthod Oral Surg. 1947;33(7):B532–40.CrossRefGoogle Scholar
  3. 3.
    Marcove RC, et al. Fibromyxoma of bone. A report of 3 cases. Cancer. 1964;17(9):1209–13.CrossRefPubMedGoogle Scholar
  4. 4.
    Brannon RB. Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor. Oral Maxillofac Surg Clin. 2004;16(3):359–74.CrossRefGoogle Scholar
  5. 5.
    Jaeger M, et al. A novel cell line that retains the morphological characteristics of the cells and matrix of odontogenic myxoma. J Oral Pathol Med. 2000;29(3):129–38.CrossRefPubMedGoogle Scholar
  6. 6.
    Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumours. 2nd ed. New York: Springer-Verlag; 1992.CrossRefGoogle Scholar
  7. 7.
    Keszler A, Dominguez FV, Giannunzio G. Myxoma in childhood: an analysis of 10 cases. J Oral Maxillofac Surg. 1995;53(5):518–21.CrossRefPubMedGoogle Scholar
  8. 8.
    Shah A, et al. Odontogenic myxoma of the maxilla: a report of a rare case and review on histogenetic and diagnostic concepts. Natl J Maxillofac Surg. 2011;2(2):189.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Thompson LD, Wenig BM. Diagnostic pathology, head and neck. 2nd ed. Philadelphia, PA: Elsevier; 2016. p. 94–5.Google Scholar
  10. 10.
    Meleti M, et al. Odontogenic myxofibroma: a concise review of the literature with emphasis on the surgical approach. Med Oral Patol Oral Cir Bucal. 2015;20(1):e1–6.CrossRefPubMedGoogle Scholar
  11. 11.
    Harder F. Myxomas of the jaws. Int J Oral Surg. 1978;7(3):148–55.CrossRefPubMedGoogle Scholar
  12. 12.
    Slootweg PJ, Wittkampf AR. Myxoma of the jaws: an analysis of 15 cases. J Maxillofac Surg. 1986;14:46–52.CrossRefPubMedGoogle Scholar
  13. 13.
    Kaffe I, Naor H, Buchner A. Clinical and radiological features of odontogenic myxoma of the jaws. Dentomaxillofac Radiol. 1997;26(5):299–303.CrossRefPubMedGoogle Scholar
  14. 14.
    Haser GC, et al. Pediatric odontogenic fibromyxoma of the mandible: case report and review of the literature. Head Neck. 2016;38(1):E25–8.CrossRefPubMedGoogle Scholar
  15. 15.
    Abiose B, Ajagbe H, Thomas O. Fibromyxomas of the jawbones—a study of ten cases. Br J Oral Maxillofac Surg. 1987;25(5):415–21.CrossRefPubMedGoogle Scholar
  16. 16.
    Koseki T, et al. Computed tomography of odontogenic myxoma. Dentomaxillofac Radiol. 2014;32(3):160–5.CrossRefGoogle Scholar
  17. 17.
    Stout AP. Myoxma, the tumor of primitive mesenchyme. Ann Surg. 1948;127(4):706.CrossRefPubMedGoogle Scholar
  18. 18.
    Dietrich E-M, et al. Odontogenic fibromyxoma of the maxilla: a case report and review of the literature. Case Reports Med. 2011;2011:238712.CrossRefGoogle Scholar
  19. 19.
    Brierley DJ, Hunter KD. Odontogenic tumours. Diagn Histopathol. 2015;21(9):370–9.CrossRefGoogle Scholar
  20. 20.
    Decoteau C, Oreadi D. A clinico-pathologic correlation: fibromyxoma. J Mass Dent Soc. 2014;63(3):46–8.PubMedGoogle Scholar
  21. 21.
    Zayet MK, Eiid SB. Multiple fibromyxomas of the jaws: a case report. Imaging Sci Dent. 2014;44(3):237–41.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Infante-Cossio P, et al. Myxofibroma of the maxilla. Reconstruction with iliac crest graft and dental implants after tumor resection. Med Oral Patol Oral Cir Bucal. 2011;16(4):e532–36.CrossRefPubMedGoogle Scholar
  23. 23.
    Shahoon H, et al. Odontogenic fibromyxoma and odontogenic cyst in an eight year old boy: three-year follow-up. J Dent Res Dent Clin Dent Prospects. 2009;3(3):103–5.PubMedPubMedCentralGoogle Scholar
  24. 24.
    Sato K, et al. Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement. Pathol Int. 2010;60(11):760–4.CrossRefPubMedGoogle Scholar
  25. 25.
    Mehrotra D, Kamboj M. Recurrent odontogenic myxofibroma of the mandible in a 12 year old: an illustrative case report. J Clin Pediatr Dent. 2008;32(4):309–12.CrossRefPubMedGoogle Scholar
  26. 26.
    Reddy GS, et al. Odontogenic fibromyxoma of maxilla: a rare case report. Case Rep Dent. 2013;2013:345479.PubMedPubMedCentralGoogle Scholar
  27. 27.
    Wright JM, et al. Odontogenic tumors, WHO 2005: where do we go from here? Head Neck Pathol. 2014;8(4):373–82.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Schneider L, Weisinger E. Odontogenic fibromyxoma arising from the periodontal ligament. J Periodontol. 1975;46(8):493–7.CrossRefPubMedGoogle Scholar
  29. 29.
    Reddy SP, Naag A, Kashyap B. Odontogenic myxoma: report of two cases. Natl J Maxillofac Surg. 2010;1(2):183.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Goldblatt LI. Ultrastructural study of an odontogenic myxoma. Oral Surg Oral Med Oral Pathol. 1976;42(2):206–20.CrossRefPubMedGoogle Scholar
  31. 31.
    Slootweg P, Bos T, Straks W. Glycosaminoglycans in myxoma of the jaw: a biochemical study. J Oral Pathol Med. 1985;14(4):299–306.CrossRefGoogle Scholar
  32. 32.
    Kim J, Ellis GL. Dental follicular tissue: misinterpretation as odontogenic tumors. J Oral Maxillofac Surg. 1993;51(7):762–7.CrossRefPubMedGoogle Scholar
  33. 33.
    Kumar N, et al. Odontogenic myxoma. J Maxillofac Oral Surg. 2014;13(2):222–6.CrossRefPubMedGoogle Scholar
  34. 34.
    Farman AG, et al. Myxofibroma of the jaws. Br J Oral Surg. 1977;15(1):3–18.CrossRefPubMedGoogle Scholar
  35. 35.
    Hammad HM, et al. Chondromyxoid fibroma of the jaws. Case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(3):293–300.CrossRefPubMedGoogle Scholar
  36. 36.
    Landa LE, et al. Recurrent myxoma of the zygoma: a case report. J Oral Maxillofac Surg. 2002;60(6):704–8.CrossRefPubMedGoogle Scholar
  37. 37.
    Neville BW, et al. Oral and maxillofacial pathology. 4th ed. St. Louis, MO: Elsevier; 2016. p. 681.Google Scholar
  38. 38.
    Khatib B, Pogrel MA. Desmoplastic fibroma of the mandible in young children-a case series. Int J Oral Maxillofac Surg. 2017;46(2):173–80.CrossRefPubMedGoogle Scholar
  39. 39.
    Said-Al-Naief N, et al. Desmoplastic fibroma of the jaw: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(1):82–94.CrossRefPubMedGoogle Scholar
  40. 40.
    Graadt van Roggen JF, Hogendoorn PC, Fletcher CD. Myxoid tumours of soft tissue. Histopathology. 1999;35(4):291–312.CrossRefPubMedGoogle Scholar
  41. 41.
    Cowan ML, et al. Low-grade fibromyxoid sarcoma of the head and neck: a clinicopathologic series and review of the literature. Head Neck Pathol. 2016;10(2):161–6.CrossRefPubMedGoogle Scholar
  42. 42.
    Downs-Kelly E, et al. The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms. Am J Surg Pathol. 2008;32(1):8–13.CrossRefPubMedGoogle Scholar
  43. 43.
    Kraft S, Fletcher CD. Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous “leiomyosarcoma”. Am J Surg Pathol. 2011;35(4):599–607.CrossRefPubMedGoogle Scholar
  44. 44.
    Parham DM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol. 2001;14(5):506–14.CrossRefPubMedGoogle Scholar
  45. 45.
    Jo VY, Fletcher CD. p63 immunohistochemical staining is limited in soft tissue tumors. Am J Clin Pathol. 2011;136(5):762–6.CrossRefPubMedGoogle Scholar
  46. 46.
    Prescott RJ, et al. Superficial acral fibromyxoma: a clinicopathological study of new 41 cases from the U.K.: should myxoma (NOS) and fibroma (NOS) continue as part of 21st-century reporting? Br J Dermatol. 2008;159(6):1315–21.CrossRefPubMedGoogle Scholar
  47. 47.
    Chaudhuri K, et al. Low-grade fibromyxoid sarcoma involving the mandible: a diagnostic dilemma. J Oral Maxillofac Pathol. 2016;20(2):334.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Wincewicz A, et al. Role of immunohistochemical and histochemical profiling in H&E-based diagnosis of scrotal leiomyosarcoma of dartos muscle. Folia Histochem Cytobiol. 2013;51(4):339–42.CrossRefPubMedGoogle Scholar
  49. 49.
    Iwata J, Fletcher CD. Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: a systematic study of 100 cases. Pathol Int. 2000;50(1):7–14.CrossRefPubMedGoogle Scholar
  50. 50.
    Yu Y, et al. Investigation of IGF2, IGFBP2 and p63 proteins in rhabdomyosarcoma tumors. Growth Horm IGF Res. 2017;33:17–22.CrossRefPubMedGoogle Scholar
  51. 51.
    Wu PX, et al. Embryonal rhabdomyosarcoma of the paranasal sinuses: a case report and review of literature. Int J Clin Exp Med. 2014;7(8):2369–72.PubMedPubMedCentralGoogle Scholar
  52. 52.
    Fraternali Orcioni G, et al. Primary embryonal spindle cell cardiac rhabdomyosarcoma: case report. Pathol Res Pract. 2010;206(5):325–30.CrossRefPubMedGoogle Scholar
  53. 53.
    Nielsen GP, et al. Chondromyxoid fibroma: a tumor showing myofibroblastic, myochondroblastic, and chondrocytic differentiation. Mod Pathol. 1999;12(5):514–7.PubMedGoogle Scholar
  54. 54.
    Hicks J, Flaitz C. Rhabdomyosarcoma of the head and neck in children. Oral Oncol. 2002;38(5):450–9.CrossRefPubMedGoogle Scholar
  55. 55.
    Muzio LL, et al. Odontogenic myxoma of the jaws a clinical, radiologic, immunohistochemical, and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(4):426–33.CrossRefPubMedGoogle Scholar
  56. 56.
    Chen C-T, Chen Y-R, Tung T-C. Maxillary myxoma treated with wide resection and immediate reconstruction: a case report. Ann Plast Surg. 1997;39(1):87–93.CrossRefPubMedGoogle Scholar
  57. 57.
    Aquilino RN, et al. Odontogenic myxoma in the maxilla: a case report and characteristics on CT and MR. Oral Oncol EXTRA, 2006;42(4):133–6.CrossRefGoogle Scholar
  58. 58.
    Batsakis JG. Myxomas of soft tissues and the facial skeleton. Ann Otol Rhinol Laryngol. 1987;96(5):618–9.CrossRefPubMedGoogle Scholar
  59. 59.
    Ghosh BC, et al. Myxoma of the jaw bones. Cancer. 1973;31(1):237–40.CrossRefPubMedGoogle Scholar
  60. 60.
    Williams T. Aggressive odontogenic cysts and tumors. Oral Maxillofac Surg Clin North Am. 1997;9:329–38.Google Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Thabet Alhousami
    • 1
    • 2
  • Amarpreet Sabharwal
    • 3
  • Shivane Gupta
    • 4
  • Alfredo Aguirre
    • 1
    • 5
  • Etern Park
    • 4
    • 7
  • Jill M. Kramer
    • 1
    • 5
    • 6
  1. 1.Department of Oral Diagnostics Sciences, School of Dental MedicineUniversity at Buffalo, The State University of New YorkBuffaloUSA
  2. 2.Department of Basic and Clinical Oral Sciences, Faculty of DentistryUmm Al-Qura UniversityMakkahSaudi Arabia
  3. 3.Department of Endodontics and Periodontics, School of Dental MedicineUniversity at Buffalo, The State University of New YorkBuffaloUSA
  4. 4.Department of Oral and Maxillofacial Surgery, School of Dental MedicineUniversity at Buffalo, The State University of New YorkBuffaloUSA
  5. 5.Immco Diagnostics IncBuffaloUSA
  6. 6.Department of Oral Biology, School of Dental MedicineUniversity at Buffalo, The State University of New YorkBuffaloUSA
  7. 7.Christiana Health Care ServicesWilmington HospitalWilmingtonUSA

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