Head and Neck Pathology

, Volume 11, Issue 4, pp 427–441 | Cite as

Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review

  • Caroline Bissonnette
  • Adel Kauzman
  • Gisele N. MainvilleEmail author
Original Paper


Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border and surrounding erythema. Lesions are often initiated by minor trauma. The condition can affect any anatomical site, however the head and neck are rarely involved. Although the oral cavity is subject to recurrent minor trauma through everyday activities such as mastication and oral hygiene, as well as during dental treatment, oral lesions appear to be extremely rare. In an effort to provide a detailed explanation of the oral manifestations of PG, a systematic search was conducted using medical databases. A total of 20 cases of PG with oral involvement were reported in the English and French literature. The objectives of this article are to present the pertinent diagnostic criteria and to discuss the differential diagnosis and therapeutic modalities.


Pyoderma gangrenosum Persistent oral ulcer Oral Oropharyngeal 


Compliance with Ethical Standards

Conflict of interest

Caroline Bissonnette declares that she has no conflict of interest. Adel Kauzman declares that he has no conflict of interest. Gisele N. Mainville declares that she has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Caroline Bissonnette
    • 1
  • Adel Kauzman
    • 2
  • Gisele N. Mainville
    • 2
    Email author
  1. 1.Resident, Multidisciplinary Residency Program, Faculty of DentistryUniversite de MontrealMontrealCanada
  2. 2.Oral and Maxillofacial Pathologist, Department of Stomatology, Faculty of DentistryUniversite de MontrealMontrealCanada

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