Head and Neck Pathology

, Volume 10, Issue 1, pp 60–67 | Cite as

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

  • James S. LewisJr.Email author
Special Issue: Sinonasal Tract Pathology. Guest Editors: Justin Bishop, MD and Alessandro Franchi, MD


The sinonasal tract is one of the least frequent sites for squamous cell carcinoma in the head and neck. However, it is still a complex tumor type for pathologists because there are numerous histologic variants with unusual morphologic features, several non-squamous carcinomas in the differential diagnosis that can have similar morphology and even squamous differentiation, and because of the increasing recognition of human papillomavirus (HPV) in a subset of the tumors. In addition, the unique and complex anatomy of the sinonasal tract can make proper staging and management of patients’ tumors quite challenging. This article reviews sinonasal tract squamous cell carcinoma in depth and provides the latest data on Schneiderian papillomas and HPV in their pathogenesis.


Sinonasal Squamous cell carcinoma Human papillomavirus Nonkeratinizing 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Pathology, Microbiology, and ImmunologyVanderbilt University Medical CenterNashvilleUSA
  2. 2.Department of OtolaryngologyVanderbilt University Medical CenterNashvilleUSA

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