Head and Neck Pathology

, Volume 7, Issue 1, pp 35–39 | Cite as

Unmasking MASC: Bringing to Light the Unique Morphologic, Immunohistochemical and Genetic Features of the Newly Recognized Mammary Analogue Secretory Carcinoma of Salivary Glands

North American Society of Head and Neck Pathology Companion Meeting, March 3, 2013, Baltimore, Maryland


Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is characterized by its striking morphologic and molecular similarities to secretory carcinoma of the breast. This review highlights the characteristic clinical, histologic, immunophenotypic, and molecular features of MASC, and draws attention to the differential diagnosis of this increasingly recognized tumor.


Mammary analogue secretory carcinoma Secretory carcinoma Acinic cell carcinoma ETV6–NTRK3 Mammaglobin 


  1. 1.
    Skalova A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6–NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.PubMedGoogle Scholar
  2. 2.
    Bishop JA, Yonescu R, Batista D et al. Most non-parotid “acinic cell carcinomas” represent mammary analoge secretory carcinomas. Am J Surg Pathol. 2013 (in Press).Google Scholar
  3. 3.
    Bishop JA, Yonescu R, Batista DA et al. Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol. 2012 (in Press).Google Scholar
  4. 4.
    Kratochvil FJ 3rd, Stewart JC, Moore SR. Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:630–5.PubMedCrossRefGoogle Scholar
  5. 5.
    Levine P, Fried K, Krevitt LD et al. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: Another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol. 2012 (in Press).Google Scholar
  6. 6.
    Pisharodi L. Mammary analog secretory carcinoma of salivary gland: cytologic diagnosis and differential diagnosis of an unreported entity. Diagn Cytopathol. 2013;41(3):239–41.Google Scholar
  7. 7.
    Chiosea SI, Griffith C, Assaad A, et al. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 2012;61:387–94.PubMedCrossRefGoogle Scholar
  8. 8.
    Chiosea SI, Griffith C, Assaad A, et al. The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma. Am J Surg Pathol. 2012;36:343–50.PubMedCrossRefGoogle Scholar
  9. 9.
    Ito S, Ishida E, Skalova A, et al. Case report of Mammary Analog Secretory Carcinoma of the parotid gland. Pathol Int. 2012;62:149–52.PubMedCrossRefGoogle Scholar
  10. 10.
    Lei Y, Chiosea SI. Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 2012;6(2):166–70.Google Scholar
  11. 11.
    Connor A, Perez-Ordonez B, Shago M, et al. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36:27–34.PubMedCrossRefGoogle Scholar
  12. 12.
    Fehr A, Loning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6–NTRK3 gene fusion. Am J Surg Pathol. 2011;35:1600–2.PubMedCrossRefGoogle Scholar
  13. 13.
    Rastatter JC, Jatana KR, Jennings LJ, et al. Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. Otolaryngol Head Neck Surg. 2012;146:514–5.PubMedCrossRefGoogle Scholar
  14. 14.
    Petersson F, Lian D, Chau YP, et al. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology. Head Neck Pathol. 2012;6:135–9.PubMedCrossRefGoogle Scholar
  15. 15.
    Griffith C, Seethala R, Chiosea SI. Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma. Virchows Arch. 2011;459:117–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Sams RN, Gnepp DR. P63 Expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. Head Neck Pathol. 2012 (in Press).Google Scholar
  17. 17.
    Tognon C, Knezevich SR, Huntsman D, et al. Expression of the ETV6–NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2:367–76.PubMedCrossRefGoogle Scholar
  18. 18.
    Knezevich SR, McFadden DE, Tao W, et al. A novel ETV6–NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184–7.PubMedCrossRefGoogle Scholar
  19. 19.
    Rubin BP, Chen CJ, Morgan TW, et al. Congenital mesoblastic nephroma t(12, 15) is associated with ETV6–NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Am J Pathol. 1998;153:1451–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Kralik JM, Kranewitter W, Boesmueller H, et al. Characterization of a newly identified ETV6–NTRK3 fusion transcript in acute myeloid leukemia. Diagn Pathol. 2011;6:19.PubMedCrossRefGoogle Scholar
  21. 21.
    Walz C, Erben P, Ritter M, et al. Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3. Blood. 2011;118:2239–42.PubMedCrossRefGoogle Scholar
  22. 22.
    Gardner DG, Bell ME, Wesley RK, et al. Acinic cell tumors of minor salivary glands. Oral Surg Oral Med Oral Pathol. 1980;50:545–51.PubMedCrossRefGoogle Scholar
  23. 23.
    Omlie JE, Koutlas IG. Acinic cell carcinoma of minor salivary glands: a clinicopathologic study of 21 cases. J Oral Maxillofac Surg. 2010;68:2053–7.PubMedCrossRefGoogle Scholar
  24. 24.
    Castellanos JL, Lally ET. Acinic cell tumor of the minor salivary glands. J Oral Maxillofac Surg. 1982;40:428–31.PubMedCrossRefGoogle Scholar
  25. 25.
    Zbaeren P, Lehmann W, Widgren S. Acinic cell carcinoma of minor salivary gland origin. J Laryngol Otol. 1991;105:782–5.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA

Personalised recommendations