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Head and Neck Pathology

, Volume 7, Issue 2, pp 203–210 | Cite as

The Non-ossifying Fibroma: A Case Report and Review of the Literature

  • Leah M. BowersEmail author
  • Donald M. Cohen
  • Indraneel Bhattacharyya
  • James C. PettigrewJr.
  • Mary F. Stavropoulos
Case Report

Abstract

The non-ossifying fibroma (NOF) is a benign, non-neoplastic lesion most commonly seen in the metaphyses of the long bones in children. While rare, the NOF has been reported in the mandible. The NOF in the extra-gnathic skeleton has a characteristic radiographic appearance, is typically asymptomatic and has a variable histologic make-up. Correlation of the radiographic appearance, clinical presentation and histopathology allows for differentiation of the NOF from odontogenic and non-odontogenic cysts and tumors. We report a new case of this interesting entity and review the radiographic, clinical and histologic features of the gnathic NOF reported in the literature. A thorough search of the English language literature returned a total of 19 cases of NOF involving the gnathic bones.

Keywords

Non-ossifying fibroma Benign fibrous histiocytoma Fibrous cortical defect Mandible 

References

  1. 1.
    Sontag LW, Pyle DI. The appearance and nature of cyst-like areas in distal femoral metaphyses of children. Am J Roentgenol Radiat Ther. 1941;46:185–8.Google Scholar
  2. 2.
    Jaffe HL, Lichtenstein L. Non-osteogenic fibroma of bone. Am J Pathol. 1942;18:205–20.PubMedGoogle Scholar
  3. 3.
    Schajowicz F, Ackerman LV, Sissons HA, et al. International histological classification of tumors (histological typing of bone tumors). Geneva: World Health Organization; 1993.CrossRefGoogle Scholar
  4. 4.
    Mizukawa N, Nishijima Y, Nishijima K. Metaphyseal fibrous defect (non-ossifying fibroma) in the mandible. A case report. Int J Oral Maxillofac Surg. 1997;26:129–30.PubMedCrossRefGoogle Scholar
  5. 5.
    Chrcanovic B, Albanese AL, Freire-Maia B, et al. Non-ossifying fibroma (metaphyseal fibrous defect) of the mandible. Oral Maxillofac Surg. 2011;4:233–7.CrossRefGoogle Scholar
  6. 6.
    Fletcher CDM, Unni KK, Mertens F. World Health Organization: classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002.Google Scholar
  7. 7.
    Dahlin DC. Fibroma (nonosteogenic fibroma of bone, metaphyseal fibrous defect), myxoma, cortical desmoid, fibromatosis, and “Xanthoma”. In: Thomas CC, editor. Bone tumors. general aspects and data on 6,221 cases, 3rd ed. Springfield, IL: Charles C Thomas; 1978. p. 122–36.Google Scholar
  8. 8.
    Betsy M, Kupersmith LM, Springfield DS. Metaphyseal fibrous defects. J Am Acad Orthop Surg. 2004;12:89–95.PubMedGoogle Scholar
  9. 9.
    Glockenberg A, Sobel E, Noel JF. Nonossifying fibroma. Four cases and review of the literature. J Am Podiatr Med Assoc. 1997;87(2):66–9.PubMedGoogle Scholar
  10. 10.
    Hudson JW, Livesay KW, McCoy JM. Condylar lesion. J Oral Maxillofac Surg. 2003;61:824–6.PubMedCrossRefGoogle Scholar
  11. 11.
    Park JK, Levy BA, Hanley JB. Non-ossifying fibroma of the mandible: report of a case. J Baltim Coll Dent Surg. 1982;35:1–5.Google Scholar
  12. 12.
    Liaw WJ, So TK, Yao YT. Non-ossifying fibroma of mandible. A case report. J Formos Med Assoc. 1979;78:795–802.Google Scholar
  13. 13.
    Blau RA, Zwick DL, Westphal RA. Multiple non-ossifying fibromas. A case report. J Bone Joint Surg Am. 1988;70:299–304.PubMedGoogle Scholar
  14. 14.
    Shaffer LG, Tommerup N, editors. ISCN 2005: an international system for human cytogenetic nomenclature. Basel: S. Karger; 2005.Google Scholar
  15. 15.
    Brassesco MS, Valera ET, Engel EE, et al. Clonal complex chromosome aberration in non-ossifying fibroma. Pediatr Blood Cancer. 2010;54:764–7.PubMedGoogle Scholar
  16. 16.
    Makek M. Non-ossifying fibroma of the mandible. A common lesion with unusual location. Arch Orthop Trauma Surg. 1980;96:225–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Quinn JH, Graves LR, Leonard GI. Unusual histiocytic lesion of the mandible: report of a case. J Oral Surg. 1970;28:528–30.PubMedGoogle Scholar
  18. 18.
    Ide F, Kusuhara S, Onuma H, et al. Xanthic variant of the non-ossifying fibroma (so called xanthofibroma) of the mandible: an ultrastructural study. Acta Pathol Jpn. 1982;32:135–42.PubMedGoogle Scholar
  19. 19.
    Elzay RP, Mills S, Kay S. Fibrous defect (non-ossifying fibroma) of the mandible. Oral Surg Oral Med Oral Pathol. 1984;58:402–7.PubMedCrossRefGoogle Scholar
  20. 20.
    Aldred MJ, Breckon JJW, Holland CS. Non-osteogenic fibroma of the mandibular condyle. Br J Oral Maxillofac Surg. 1989;27:412–6.PubMedCrossRefGoogle Scholar
  21. 21.
    Rudy HN, Scheingold SS. Solitary xanthogranuloma of the mandible. Report of a case. Oral Surg Oral Med Oral Pathol. 1964;18:262–71.PubMedCrossRefGoogle Scholar
  22. 22.
    Bessho K, Murakami K, Nishida M, et al. Non-ossifying fibroma of the mandible: case report and review of literature. Jpn J Oral Maxillofac Surg. 1986;32:291–6.CrossRefGoogle Scholar
  23. 23.
    Huvos AG. Nonossifying Fibroma. In: Bone tumors: diagnosis, treatment, and prognosis. Philadelphia, PA: W. B. Saunders; 1979. p. 297–306.Google Scholar
  24. 24.
    Bailey JS, Nikitakis NG, Lopes M, et al. Non-ossifying fibroma of the mandible in a 6-year-old girl: a case report and review of the literature. J Oral Maxillofac Surg. 2001;59:815–8.PubMedCrossRefGoogle Scholar
  25. 25.
    Uçkan S, Gürol M, Mutlu N, et al. Non-ossifying fibroma of the mandible: report of a case. Br J Oral Maxillofac Surg. 1999;37:152–4.PubMedGoogle Scholar
  26. 26.
    Spjut HJ, Dorfman HD, Fechner RE, Ackerman LV. Tumors of bone and cartilage. In: Atlas of tumor pathology, second series, fascicle 5. Washington: Armed Forces Institute of Pathology; 197l. p. 249–50.Google Scholar
  27. 27.
    Harsanyi BB, Larsson A. Xanthomatous lesions of the mandible: osseous expression of non-X histiocytosis and benign fibrous histiocytoma. Oral Surg Oral Med Oral Pathol. 1988;65(5):551–66.PubMedCrossRefGoogle Scholar
  28. 28.
    Mirra JM. Fibrohistiocytic tumors intramedullary origin. In: Mirra JM, editor. Bone tumors: clinical, radiologic, and pathologic correlation. Philadelphia: Lea & Febiger; 1989. p. 692–731.Google Scholar
  29. 29.
    Hatcher CH. The pathogenesis of localized fibrous lesions in the metaphyses of long bones. Ann Surg. 1945;122:1016.CrossRefGoogle Scholar
  30. 30.
    Bhagwandeen SB. Malignant transformation of a non-osteogenic fibroma of bone. J Pathol. 1966;92:562–4.CrossRefGoogle Scholar
  31. 31.
    Heo MS, Cho HJ, Kwon KJ, et al. Benign fibrous histiocytoma in the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:276–80.PubMedCrossRefGoogle Scholar
  32. 32.
    Neville B, Damm D, Allen C, Bouquot J. Oral & maxillofacial pathology. 3rd ed. Philadelphia: Saunders; 2009. p. 729–31.Google Scholar
  33. 33.
    Roche WC, Krishnan V, McDaniel RK. Fibrous defect of the mandible: a case report and literature review. J Oral Maxillofac Surg. 1993;51:809–11.PubMedCrossRefGoogle Scholar
  34. 34.
    Fechner RE, Mills SE. Tumors of the bone and joints. In: Rosai J, Sobin LH, editors. Atlas of tumor pathology, 3rd series, 8th fascicle. Washington: AFIP; 1993. p. 129–44.Google Scholar
  35. 35.
    Hamada T, Ito H, Araki Y, et al. Benign fibrous histiocytoma of the femur: review of three cases. Skeletal Radiol. 1996;25:25–9.PubMedCrossRefGoogle Scholar
  36. 36.
    Campanacci M, Laus M, Boriani S. Multiple non-ossifying fibromata with extraskeletal anomalies: a new syndrome? J Bone Joint Surg Br. 1983;65:627–32.PubMedGoogle Scholar
  37. 37.
    Mirra JM, Gold RH, Rand F. Disseminated non-ossifying fibromas in association with café-au-lait spots (Jaffe-Campanacci syndrome). Clin Orthop Relat Res. 1982;168:192–205.PubMedGoogle Scholar
  38. 38.
    Abdelsayed RA, Sharma S, Ferguson H. Fibrous cortical defect (nonossifying fibroma) of the mandibular ramus: report of 2 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:504–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Leah M. Bowers
    • 1
    Email author
  • Donald M. Cohen
    • 1
  • Indraneel Bhattacharyya
    • 1
  • James C. PettigrewJr.
    • 1
  • Mary F. Stavropoulos
    • 2
  1. 1.Oral and Maxillofacial Diagnostic SciencesUniversity of FloridaGainesvilleUSA
  2. 2.Department of Oral and Maxillofacial SurgeryUniversity of FloridaGainesvilleUSA

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