Head and Neck Pathology

, Volume 7, Issue 2, pp 203–210 | Cite as

The Non-ossifying Fibroma: A Case Report and Review of the Literature

  • Leah M. BowersEmail author
  • Donald M. Cohen
  • Indraneel Bhattacharyya
  • James C. PettigrewJr.
  • Mary F. Stavropoulos
Case Report


The non-ossifying fibroma (NOF) is a benign, non-neoplastic lesion most commonly seen in the metaphyses of the long bones in children. While rare, the NOF has been reported in the mandible. The NOF in the extra-gnathic skeleton has a characteristic radiographic appearance, is typically asymptomatic and has a variable histologic make-up. Correlation of the radiographic appearance, clinical presentation and histopathology allows for differentiation of the NOF from odontogenic and non-odontogenic cysts and tumors. We report a new case of this interesting entity and review the radiographic, clinical and histologic features of the gnathic NOF reported in the literature. A thorough search of the English language literature returned a total of 19 cases of NOF involving the gnathic bones.


Non-ossifying fibroma Benign fibrous histiocytoma Fibrous cortical defect Mandible 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Leah M. Bowers
    • 1
    Email author
  • Donald M. Cohen
    • 1
  • Indraneel Bhattacharyya
    • 1
  • James C. PettigrewJr.
    • 1
  • Mary F. Stavropoulos
    • 2
  1. 1.Oral and Maxillofacial Diagnostic SciencesUniversity of FloridaGainesvilleUSA
  2. 2.Department of Oral and Maxillofacial SurgeryUniversity of FloridaGainesvilleUSA

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