Head and Neck Pathology

, Volume 7, Issue 1, pp 54–63 | Cite as

Clinical and Radiological Profile of Ameloblastic Fibro-Odontoma: an Update on an Uncommon Odontogenic Tumor Based on a Critical Analysis of 114 Cases

  • Amos Buchner
  • Israel Kaffe
  • Marilena VeredEmail author
Original Paper


Ameloblastic fibro-odontoma is an uncommon benign tumor of the jaws that belongs to the group of mixed odontogenic tumors. The descriptions of its clinical and radiological features in the literature are not always accurate and sometimes even contradictory. The aim of the present study was to critically evaluate their clinical and radiological features as reported in the English-language literature. A total of 114 well–documented cases of ameloblastic fibro-odontomas (103 from publications and 11 of our own new cases) were analyzed. The patients’ age ranged from 8 months to 26 years (mean 9.6). There were 74 (65 %) males, with a male-to-female ratio of 1.85:1 (P = 0.001). The mandible was involved in 74 (65 %) cases, and the mandible-to-maxilla ratio was 1.85:1 (P < 0.001). Nearly 80 % of the lesions were located in the posterior region of the jaws, and most (58 %) were in the posterior mandible. Radiographically, most of the lesions were unilocular and only a few (~10 %) were multilocular. Most lesions were mixed radiolucent-radiopaque, and only a few (~5 %) were radiolucent. Almost all lesions (~92 %) were associated with the crown of an unerupted tooth/teeth. This comprehensive analysis of a large number of patients with an uncommon lesion revealed that ameloblastic fibro-odontomas are significantly more common in males and in the mandible, and that multilocular lesions are uncommon. It also revealed that, based on their clinical and radiological features, some of them are probably true neoplasms while others appear to be developing odontomas (hamartomas).


Ameloblastic fibro-odontoma Mixed odontogenic tumors Ameloblastic fibroma Developing odontoma Odontoma 



The study was supported by the Ed and Herb Stein Chair in Oral Pathology, Tel Aviv University. The authors would like to thank Prof. S. Calderon and Prof. S. Taicher for the radiographs of cases number 3 and 11, and to Ms. Esther Eshkol for editorial assistance.


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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Oral Pathology and Oral Medicine, School of Dental MedicineTel Aviv UniversityTel AvivIsrael
  2. 2.Institute of PathologyThe Chaim Sheba Medical CenterTel HashomerIsrael

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