Human papillomavirus has emerged as a major pathogen, capable of causing cancer at many different sites. In the head and neck, human papillomavirus is associated with many squamous cell carcinomas and is particularly important in the oropharynx. This is a fast moving topic with many important epidemiological, biological, pathological, and clinical features that are often confusing and misunderstood. This article introduces a series of timely reviews and editorials on this important subject in head and neck oncology.
Human papillomavirus p16 immunohistochemistry Squamous cell carcinoma Oropharynx Survival Head and neck
Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92(9):709–20.PubMedCrossRefGoogle Scholar
Nasman A, Attner P, Hammarstedt L, et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer. 2009;125(2):362–6.PubMedCrossRefGoogle Scholar
Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35.PubMedCrossRefGoogle Scholar
Adelstein DJ, Ridge JA, Gillison ML, et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute state of the science meeting, November 9–10, 2008. Head Neck. 2009;31(11):1393–422.PubMedCrossRefGoogle Scholar
Olthof NC, Straetmans JM, Snoeck R, et al. Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go? Rev Med Virol. 2012;22(2):88–105.PubMedCrossRefGoogle Scholar