Skip to main content

Advertisement

Log in

Colonic-Type Adenocarcinoma of the Base of the Tongue: A Case Report of a Rare Neoplasm

  • Case Report
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Lingual adenocarcinomas (ADC), either primary or metastatic to the tongue are extraordinarily rare neoplasms. Primary lingual adenocarcinomas are primarily of minor salivary gland origin. Two cases of primary colonic-type adenocarcinomas of the base of the tongue were recently reported for the first time in the English literature. We present an additional case of lingual intestinal-type adenocarcinoma with mucinous features that occurred in association with cervical node metastasis and discuss the clinicopathologic features and histogenetic aspects of this rare entity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Goldblatt LI, Ellis GL. Salivary gland tumors of the tongue: analysis of 55 new cases and review of the literature. Cancer. 1987;60:74–81.

    Article  PubMed  CAS  Google Scholar 

  2. Bell D, Kupferman ME, Williams MD, Rashid A, El-Naggar AK. Primary colonic-type adenocarcinoma of the base of the tongue: a previous unreported phenotype. Hum Pathol. 2009;40:1798–802.

    Article  PubMed  Google Scholar 

  3. Hassona Y, Hughes C, Prime SS. Metastatic tumors of the tongue. Oral Oncol. 2011;47:308–11.

    Article  PubMed  Google Scholar 

  4. Ellis G, Auclair P, eds. Tumors of the salivary glands. 4th ed. Washington DC: Armed Forces Institute of Pathology; 2008. p. 383–6.

  5. Ide F, Mishima K, Tanaka A, Saito I, Kusama K. Mucinous adenocarcinoma of minor salivary glands: a high-grade malignancy prone to lymph node metastasis. Vircows Arch. 2009;454:55–6.

    Article  Google Scholar 

  6. Wenig BM ed. Atlas of head and neck pathology, 2nd ed. Philadelphia, PA: Saunders-Elsevier, 2008; 121–4.

  7. Davidson NGP, Wilson A. Tongue metastasis from carcinoma of the rectum. J Laryngol Otol. 1989;103:322–3.

    Article  PubMed  CAS  Google Scholar 

  8. Gorlin FJ, Jirasek JE. Oral cysts containing gastric or intestinal mucosa: unusual embryological accident of heterotopia. Arch Otolaryngol. 1970;91:594–7.

    Article  PubMed  CAS  Google Scholar 

  9. Yom SS, Rashid A, Rosenthal DI, Elliot DD, Hanna EY, Weber RS, El-Naggar AK. Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. Mod Pathol. 2005;18:315–9.

    Article  PubMed  CAS  Google Scholar 

  10. Kennedy MT, Jordan RC, Berean KW, Perez-Odoñez B. Expression pattern of CK7, CK20, CDX-2 and villin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol. 2004;57:932–7.

    Article  PubMed  CAS  Google Scholar 

  11. Korinth D, Pacyna-Gengelbach M, Deutschmann N, Hattenberger S, Bockmühl U, Dietel M, Schroeder HG, Donhuijsen K, Petersen I. Chromosomal imbalances in wood dust-related adenocarcinomas of the inner nose and their associations with pathological parameters. J Pathol. 2005;207:207–15.

    Article  PubMed  CAS  Google Scholar 

  12. Lipsett J, Sparnon AL, Byard RW. Embryogenesis of enterocystomas-enteric duplication cysts of the tongue. Oral Surg Oral Med Oral Pathol. 1993;75:626–30.

    Article  PubMed  CAS  Google Scholar 

  13. Daley TD, Wysocki GP, Lovas GL, Smout MS. Heterotopic gastric cyst of the oral cavity. Head Neck Surg. 1984;7:168–71.

    Article  PubMed  CAS  Google Scholar 

  14. Woolgar JA, Smith AJ. Heterotopic gastrointestinal cyst of oral cavity: a developmental lesion? Oral Surg Oral Med Oral Pathol. 1988;66:223–5.

    Article  PubMed  CAS  Google Scholar 

  15. Veeneklaas GMH. Pathogenesis of intrathoracic gastrogenic cysts. AMA Am J Dis Child. 1952;83:500–7.

    PubMed  CAS  Google Scholar 

  16. Sauer C, Bickston SJ, Borowitz SM. Gastric heterotopia of the rectum. JPGN. 2010;50:329–33.

    PubMed  Google Scholar 

  17. Wolff M. Heterotopic gastric epithelium in the rectum: a report of three new gases with a review of 87 cases of gastric heterotopia in the alimentary canal. Am J Clin Pathol. 1971;55:604–16.

    PubMed  CAS  Google Scholar 

  18. Christensen WN, Sternberg SS. Adenocarcinoma of the upper esophagus arising in ectopic gastric mucosa. Two case reports and review of the literature. Am J Surg Pathol. 1987;11:397–402.

    Article  PubMed  CAS  Google Scholar 

  19. Volchok J, Jaffer A, Cooper T, Al-Sabbagh A, Cavalli G. Adenocarcinoma arising in a lingual foregut duplication cyst. Arch Otolaryngol Head Neck Surg. 2007;133:717–9.

    Article  PubMed  Google Scholar 

  20. Eaton D, Billings K, Timmons C, Booth T, Biavati MJ. Congenital foregut duplication cysts of the anterior tongue. Arch Otolaryngol Head Neck Surg. 2001;127:1484–7.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alberto Paniz Mondolfi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Slova, D., Paniz Mondolfi, A., Moisini, I. et al. Colonic-Type Adenocarcinoma of the Base of the Tongue: A Case Report of a Rare Neoplasm. Head and Neck Pathol 6, 250–254 (2012). https://doi.org/10.1007/s12105-011-0301-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-011-0301-z

Keywords

Navigation