Head and Neck Pathology

, Volume 5, Issue 2, pp 123–132 | Cite as

Development and Growth of Adenomatoid Odontogenic Tumor Related to Formation and Eruption of Teeth

  • Fumio Ide
  • Kenji Mishima
  • Kentaro Kikuchi
  • Norio Horie
  • Shigeo Yamachika
  • Kazuhito Satomura
  • Tetsuo Shimoyama
  • Hideaki Sakashita
  • Ichiro Saito
  • Kaoru Kusama
Original Paper
First Online:
Received:
Accepted:

Abstract

The number of published cases of adenomatoid odontogenic tumor (AOT) has steadily increased, and about half were reported in Asian populations. Although the clinicopathologic profile of AOT has been extensively reported, factual knowledge of its pathogenesis is rudimentary at best, and there is controversy as to precisely which odontogenic epithelium it arises from. AOT is a successional tooth-associated lesion which develops during the mixed dentition. The permanent successor differs from its deciduous predecessor in that it has an eruptive pathway from the dental follicle to the gingiva, the gubernaculum dentis. With this background in mind, the present review focuses mainly on the early development of AOT. We successfully demonstrated a close spatial relationship between AOT and the gubernaculum dentis in a typical case. From further observations of the same AOT in which an enclosed permanent canine showed enamel hypoplasia, it is possible to pinpoint areas around the crown of a developing successional tooth in continuity with the gubernaculum dentis as starting points. In addition, we discuss the unifying histogenetic concept of three clinical variants, namely, pericoronal (follicular), extracoronal (extrafollicular), (see Article note) and peripheral.

Keywords

Adenomatoid odontogenic tumor Clinical variant Enamel hypoplasia Gubernaculum dentis Histogenesis 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Fumio Ide
    • 1
    • 2
    • 3
  • Kenji Mishima
    • 1
  • Kentaro Kikuchi
    • 2
  • Norio Horie
    • 3
  • Shigeo Yamachika
    • 4
  • Kazuhito Satomura
    • 4
  • Tetsuo Shimoyama
    • 3
  • Hideaki Sakashita
    • 5
  • Ichiro Saito
    • 1
  • Kaoru Kusama
    • 2
  1. 1.Departments of Diagnostic Pathology and Oral PathologyTsurumi University School of Dental MedicineTsurumi-ku, YokohamaJapan
  2. 2.Division of Pathology, Department of Diagnostic and Therapeutic SciencesMeikai University School of DentistrySakadoJapan
  3. 3.Department of Oral SurgerySaitama Medical Center, Saitama Medical UniversityKawagoeJapan
  4. 4.Second Department of Oral and Maxillofacial SurgeryTsurumi University School of Dental MedicineYokohamaJapan
  5. 5.Second Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic SciencesMeikai University School of DentistrySakadoJapan

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