Head and Neck Pathology

, Volume 5, Issue 2, pp 101–107 | Cite as

Clear Cell Carcinoma and Clear Cell Odontogenic Carcinoma: a Comparative Clinicopathologic and Immunohistochemical Study

  • Elizabeth A. BilodeauEmail author
  • Aaron P. Hoschar
  • E. Leon Barnes
  • Jennifer L. Hunt
  • Raja R. Seethala
Original Paper


Clear cell carcinoma or hyalinizing clear cell carcinoma (CCC) and clear cell odontogenic carcinoma (CCOC) are rare, low-grade and typically indolent malignancies that can be diagnostically challenging. In this study the clinicopathologic, histologic, and immunohistochemical features of 17 CCCs and 12 CCOCs are examined. The differential diagnosis of clear cell malignancies in the head and neck is discussed. The relationship of CCCs and CCOCs to other clear cell tumors on the basis of their immunohistochemical staining patterns is postulated.


Clear cell carcinoma Clear cell odontogenic carcinoma Immunohistochemistry Histologic 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Elizabeth A. Bilodeau
    • 1
    Email author
  • Aaron P. Hoschar
    • 2
  • E. Leon Barnes
    • 3
  • Jennifer L. Hunt
    • 4
  • Raja R. Seethala
    • 3
  1. 1.Department of Diagnostic SciencesUniversity of Pittsburgh School of Dental MedicinePittsburghUSA
  2. 2.Department of PathologyThe Cleveland ClinicClevelandUSA
  3. 3.Department of PathologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Department of PathologyMassachusetts General HospitalBostonUSA

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