Head and Neck Pathology

, Volume 4, Issue 1, pp 44–48 | Cite as

Collagenous Myofibroblastic Tumor of the Mandible: Case Report of a Unique Locally Aggressive Neoplasm

  • Jason W. Nash
  • Amy C. Hessel
  • Nadarajah Vigneswaran
  • Adel K. El-Naggar
Case Report

Abstract

We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.

Keywords

Mandible Myofibroblastic neoplasm Mesenchymal tumors Odontogenic tumors 

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Copyright information

© Humana 2009

Authors and Affiliations

  • Jason W. Nash
    • 1
  • Amy C. Hessel
    • 2
  • Nadarajah Vigneswaran
    • 3
  • Adel K. El-Naggar
    • 1
    • 2
  1. 1.Department of PathologyThe University of Texas M.D. Anderson Cancer Center, Unit 85HoustonUSA
  2. 2.Head and Neck SurgeryThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of Diagnostic SciencesThe University of Texas Dental Branch at HoustonHoustonUSA

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