1H, 13C and 15N chemical shift assignments of IPSEΔNLS

  • N. Helge Meyer
  • Gabriele Schramm
  • Michael Sattler


The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1) is a major immunogenic component of schistosomes. It potently triggers the release of interleukin-4 from basophilic granulocytes in an IgE-dependent manner, suggesting a key function in the modulation of the host’s immune response to Schistosoma mansoni infection. Here we present the near complete assignment of an IPSE/alpha-1 variant, IPSEΔNLS, which comprises the core domain of the protein.


NMR Schistosoma mansoni IgE 


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • N. Helge Meyer
    • 1
    • 2
  • Gabriele Schramm
    • 3
  • Michael Sattler
    • 1
    • 2
  1. 1.Institute of Structural Biology, Helmholtz Zentrum MünchenNeuherbergGermany
  2. 2.Department Chemie, Biomolecular NMR and Center for Integrated Protein Science Munich (CiPSM)Technische Universität MünchenGarchingGermany
  3. 3.Cellular AllergologyResearch Center BorstelBorstelGermany

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