Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1
The voltage dependent anion channel (VDAC) forms a channel for metabolites and nutrients in the outer membrane of mitochondria, and it is also involved in apoptotic pathways. Here, we report sequence-specific NMR assignments for the isoform 1 of human VDAC reconstituted in lauryldimethylamine oxide (LDAO) detergent micelles. The assignments were deposited in the BMRB data base with accession number 16381.
KeywordsVoltage dependent anion channel Voltage gating β-Barrel Protein refolding Membrane protein structure Multi-dimensional decomposition (MDD) TROSY Selective labeling 4D-NOESYs Non-uniform sampling (NUS)
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