Resonance assignments for stromelysin complexed with a β-sulfonyl hydroxamate inhibitor
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The sequence specific 1H, 13C, and 15N resonance assignments for stromelysin, a Matrix metalloproteinase, are reported in this article. Almost 70% of assignable backbone and side-chain atoms were assigned in this highly dynamic protein.
KeywordsAUTOASSIGN NMR assignment Stromelysin-inhibitor complex
We thank Donald E. Harper and Martha A. Warpehoski for synthesizing the β-sulfonyl hydroxamate inhibitor and Vincent P. Marshall, Gary L. Petzold and Roger A. Poorman for supplying stromelysin.
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